Blood
01 Jan 2013
GM-CSF Vaccinations After Allogeneic Blood Stem Cell Transplantation in Patients With Advanced Myeloid Malignancies
The purpose of this study is to investigate whether the addition of a vaccine after participants reduced intensity transplant will be safe and beneficial. The vaccine used in this trial, called GVAX, will be made from the participants own leukaemia cells, and will be given between 1-4 months after transplant.
Blood
01 Jan 2013
Study to Determine the Effect and Safety of an Oral Janus Kinase 2 (JAK2)-Inhibitor in Patients with Multiple Myeloma
The purpose of this study is to determine clinical efficacy and safety of INCB018424, a small molecule Janus kinase (JAK) inhibitor, in patients with refractory or relapsed multiple myeloma. Official Title A Phase 2, Two Stage, Open-Label, Clinical Trial to Determine the Therapeutic Effect and Safety of an Oral JAK2-Inhibitor…
Blood
01 Jan 2013
Intravenous Iron in Patients With Anaemia of Chronic Kidney Disease
The objective of this study is the evaluation of the efficacy and safety of intravenous iron sucrose in anaemic patients with chronic kidney disease not on renal replacement therapy. Official Title Open Randomized Phase IV Study on Intravenous Iron in Anemic Patients With Chronic Kidney Disease. Conditions Chronic…
Blood
01 Jan 2013
Treatment of Deficient Subclass or Anti-Polysaccharide Antibody
There is no consensus on the treatment of patients with recurrent infections and isolated immunoglobulin G (IgG)-subclass deficiency and/or selective antipolysaccharide antibody deficiency. Therefore, the Dutch Inter University Working Party will start a study in which the treatment with antibiotics is compared with intravenous immunoglobulin therapy with respect to clinical…
Blood
01 Jan 2013
Characteristics of Blood-Brain Barrier Permeability in Neurological Patients
The main goal of the present study is to challenge the hypothesis that blood-brain barrier disruption following brain injury increases the risk for long-term disability, development of brain dysfunction, epileptic seizures and neuroanatomical alterations. Official Title Blood-Brain Barrier Permeability in Neurological Patients: Anatomical, Neurophysiological, and Clinical Characteristics. Conditions Traumatic…
Research and Trials
01 Jan 2013
Evaluating the Effectiveness of Financial Incentives in Promoting Weight Loss Among Obese Individuals
Obesity is a major cause of premature aging and the second leading cause of preventable mortality in the United States, accounting for approximately 110,000 deaths per year. Financial incentives have been effective in modifying a number of health behaviours but they have rarely been applied to weight loss, and to…
Research and Trials
01 Jan 2013
Energy Expenditure & Activity During & After Exercise-Induced Weight Loss
This project is aimed at determining whether an exercise-based weight loss intervention causes compensation in some component of energy expenditure such that the increase in measured energy expenditure is less than the added exercise. The study will compare two separate exercise interventions to determine if this is influenced by exercise…
Research and Trials
01 Jan 2013
Physical Activity Following Surgery Induced Weight Loss
The primary objective of this study will be to determine the effects of physical activity in patients during substantial surgery-induced weight loss. A randomised controlled physical activity intervention trial in a group of patients undergoing bariatric surgery for weight loss. The study will involve two sites with an active bariatric…
Joints
01 Jan 2013
Influence of Weight Loss or Exercise on Cartilage in Obese Knee Osteoarthritis Patients (CAROT)
Obesity and osteoarthritis (OA) co-exist in an increasing part of the population.The two diseases intertwine in several ways. The evolution in the population shows a tendency towards deterioration of both by increasing general age and weight. The two diseases share pathogenetic features and the development of one disease increases the…
