Energy Expenditure & Activity During & After Exercise-Induced Weight Loss

This project is aimed at determining whether an exercise-based weight loss intervention causes compensation in some component of energy expenditure such that the increase in measured energy expenditure is less than the added exercise. The study will compare two separate exercise interventions to determine if this is influenced by exercise intensity.

Official Title

Energy Expenditure & Activity During & After Exercise-Induced Weight Loss

Conditions

Obesity

Study Type

Interventional

Study Design

Other, Randomised, Open Label, Parallel Assignment

Further Details

Primary Outcome Measures: 

• Total daily energy expenditure, assessed using doubly labelled water

Secondary Outcome Measures:

• Total daily activity thermo genesis
• Body weight and composition

Study Start

September 2007

Eligibility & Criteria

Official Title

Energy Expenditure & Activity During & After Exercise-Induced Weight Loss

Conditions

Obesity

Study Type

Interventional

Study Design

Other, Randomised, Open Label, Parallel Assignment

Further Details

Primary Outcome Measures: 

• Total daily energy expenditure, assessed using doubly labelled water

Secondary Outcome Measures:

• Total daily activity thermo genesis
• Body weight and composition

Study Start

September 2007

Eligibility & Criteria

Eligibility

• Ages Eligible for Study: 18 Years to 55 Years
• Genders Eligible for Study: Both
• Accepts Healthy Volunteers: Yes

Criteria

Inclusion Criteria

• Body mass index (BMI) 30-35.0 kg/m2
• Age 18-45 years
• Weight stable (<2 kg weight fluctuation during previous 6 months)
• No regular exercise (> 1 bout of exercise/wk or participation in any sporting activities > 1 hr/wk)
• No self-report of acute or chronic disease (diabetes, heart diseases, and joint problems in particular)
• No current use of prescribed medications
• No plans to relocate within the next year
• No plans for extended travel (> 1 week) within the next 6 months
• No tobacco use
• For females
  • No evidence of amenorrhea (Regular menstrual cycles of 21-35 days)
  • Pre-menopausal status (self-report, to be confirmed during screening)
  • Pregnancy or lactating within the past year
  • No pregnancy or planned pregnancies; sexually active women of childbearing potential may be enrolled if they have had a tubal ligation or use one of the following means of contraception: condom, diaphragm, oral or implanted contraceptives, or intrauterine device. Women in exclusive relationships with male partners who have had a successful vasectomy will not be required to use any additional means of birth control.

Total Enrolment

40

Contact Details

Please refer to this study by its ClinicalTrials.gov identifier: NCT00622310

Contacts

Contact: Edward L Melanson      (303) 315-4087 ext 7      EXWTLOSS@uchsc.edu

Contact: Amber A Carlson      (303) 315-4087 ext 7      EXWTLOSS@uchsc.edu    

Locations

United States, Colorado
 University of Colorado, School of Medicine      Recruiting
       Aurora, Colorado, United States, 80045
       Contact: Edward L Melanson     303-315-4087 ext 7     EXWTLOSS@uchsc.edu    
       Principal Investigator: Edward L Melanson, Ph.D.            

Sponsors and Collaborators

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Total Enrolment

40

Contact Details

Please refer to this study by its ClinicalTrials.gov identifier: NCT00622310

Contacts

Contact: Edward L Melanson      (303) 315-4087 ext 7      EXWTLOSS@uchsc.edu

Contact: Amber A Carlson      (303) 315-4087 ext 7      EXWTLOSS@uchsc.edu    

Locations

United States, Colorado
 University of Colorado, School of Medicine      Recruiting
       Aurora, Colorado, United States, 80045
       Contact: Edward L Melanson     303-315-4087 ext 7     EXWTLOSS@uchsc.edu    
       Principal Investigator: Edward L Melanson, Ph.D.            

Sponsors and Collaborators

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)