Children's health
01 Jan 2013
Safety and Immunogenicity of 2 Formulations of an Intramuscular A/H5N1 Pandemic Influenza Vaccine in Children
This is an open, randomised, multicentre clinical trial.Objectives:To describe the safety profiles during the 21 days following each primary and booster injection.To describe the immune response 21 days after each primary and booster injection of each formulation.To describe the antibody persistence after the first vaccination. Official Title Conditions Influenza…
Children's health
01 Jan 2013
Comparison of Abnormal Cortical Development in Brain Malformations on Postmortem Imaging With Autopsy
Mental Health
01 Jan 2013
Physiological Brain Atlas Development
The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the targeting and use of DBS implants for Parkinson’s Disease, Dystonia, Essential Tremor, and OCD. Official Title Physiological Brain Atlas Development. Conditions Parkinson’s Disease Dystonia Essential Tremor OCD Study…
Neurology
01 Jan 2013
Discrete Hypothermia in the Management of Traumatic Brain Injury
The primary goal of this project is to demonstrate the feasibility and clinical benefits of a new rapid treatment for secondary treatment for secondary brain injury called Discrete Cerebral Hypothermia System by CoolSystems, Inc., Berkley, CA. This device induced hypothermia in the adult brain without significant whole body hypothermia. Discrete…
Mental Health
01 Jan 2013
Deep Brain Stimulation for Parkinson’s Disease Trial
The purpose of this trial is to evaluate the effect of deep brain stimulation in the the globus pallidus (Gpi) and the subthalamic nucleus (STN) on motor, neuropsychological and psychiatric function, and quality of life in patients with Parkinson’s disease. Official Title Deep Brain Stimulation for Parkinson’s Disease Trial.
Bone
01 Jan 2013
A Phase III Trial to Evaluate the Effectiveness and Safety of Tapentadol(CG5503) Extended Release (ER) in Patients With Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee
The purpose of this trial is to evaluate the effectiveness (level of pain control) and safety of orally administrated CG5503 Extended Release (ER) (base) at doses of 100-250 mg twice daily in patients with moderate to severe chronic pain due to osteoarthritis of the knee, in comparison with placebo and…
Bone
01 Jan 2013
Pamidronate to Treat Osteogenesis Imperfecta in Children
This study will evaluate the effect of pamidronate-a drug that decreases bone resorption (breakdown)-on osteogenesis imperfecta. This is a genetic disorder of collagen, the major protein in bone. The abnormal collagen causes weak bones, and children with severe osteogenesis imperfecta sustain many fractures throughout their lives. They also have growth…
Bone
01 Jan 2013
Cytokine Gene Polymorphisms in Bone Marrow Failure
This study will examine whether cytokine gene polymorphisms affect the progression or response to therapy of bone marrow failure disorders. Cytokine genes instruct cells to produce proteins called cytokines that influence immune system response. As with many genes, the cytokine genes differ slightly from person to person. These differences are…
Research and Trials
01 Jan 2013
Alemtuzumab to Treat Severe Aplastic Anaemia
This study will evaluate the safety and usefulness of a new immunosuppressive drug, alemtuzumab (Campath®), in patients with severe aplastic anemia (SAA). SAA is a rare and serious blood disorder in which the bone marrow stops making red blood cells, white blood cells and platelets. Alemtuzumab is a monoclonal antibody…
