Characteristics of Blood-Brain Barrier Permeability in Neurological Patients

The main goal of the present study is to challenge the hypothesis that blood-brain barrier disruption following brain injury increases the risk for long-term disability, development of brain dysfunction, epileptic seizures and neuroanatomical alterations.

Official Title

Blood-Brain Barrier Permeability in Neurological Patients: Anatomical, Neurophysiological, and Clinical Characteristics.

Conditions

• Traumatic Brain Injury
• Cerebral Infarction
• Cerebral Haemorrhage

Study Type

Observational

Study Design

Natural History, Longitudinal, Defined Population, Retrospective/Prospective Study.

Further Details

Study Start

Eligibility & Criteria

• Ages Eligible for Study: 16 Years to 75 Years
• Genders Eligible for Study: Bot
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• One week following:
  • Traumatic Brain Injury
  • Cerebro- Vascular Accident
• Subsequent brain CT showed cerebral cortex injury.

Exclusion Criteria:

• A known ailment of the central nervous system.
• Use of medications or illicit drugs that significantly affect the central nervous system.
• tourist or temporary residents not available for follow-up.
• For MRI examinations: heart pacemaker, metal implants, or metal shrapnel.

Total Enrolment

100

Contact Details

 Location:

Soroka Medical Center Executive Office
Beer Sheva, 84101
Israel

Contact:

Alon Friedman, MD/PhD
Phone No.: +972-8-640-3408
Fax No.: 972-8-627-7364
Email: alonf@bgu.ac.il