Blood
01 Jan 2013
Tipifarnib in Treating Patients With Myelofibrosis and Myeloid Metaplasia
RATIONALE: Tipifarnib may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth. PURPOSE: Phase II trial to study the effectiveness of tipifarnib in treating patients who have myelofibrosis with myeloidmetaplasia. Condition: – chronic idiopathic myelofibrosis – Polycythemia Vera – Essential Thrombocythemia…
Blood
01 Jan 2013
Induction of Stable Chimerism for Sickle Cell Anemia
To investigate a modified hematopoeitic cell transplantation (HCT) procedure for sickle cell disease that significantly reduces the toxicity of HCT, yet retains its therapeutic benefit. To investigate a modified hematopoeitic cell transplantation (HCT) procedure for sickle cell disease that significantly reduces the toxicity of HCT, yet retains its therapeutic benefit.
Cancer
01 Jan 2013
Chemotherapy and Radiation Therapy in Treating Infants With Brain Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining radiation therapy with chemotherapy may kill more tumor cells. RATIONALE: Drugs used in chemotherapy use different ways to stop tumor…
Cancer
01 Jan 2013
XK469 in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.PURPOSE: Phase I trial to study the effectiveness of XK469 in…
Cancer
01 Jan 2013
“REDUCE” – A Clinical Research Study To Reduce The Incidence Of Prostate Cancer In Men Who Are At Increased Risk
Purpose This 4-year study will compare how safe and effective an oral investigational medicine is (compared to placebo) in preventing the development of prostate cancer in men that are defined by the study entrance criteria as being at an increased risk for prostate cancer. Study visits to the clinic…
Cancer
01 Jan 2013
Specialized Blood Cell Transplants for Cancers of the Blood and Bone Marrow
Purpose The are a variety of cancerous diseases of the blood and bone marrow that can be potentially cured by bone marrow transplantation (BMT). Diseases like leukemia, lymphoma, and multiple myeloma are among the conditions that can be treated with BMT. Official Title Non-myeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic…
Infections
01 Jan 2013
Identification of new organelle in apicomplexan parasites which can serve as a drug target.
The recent discovery of a new organelle in several parasites including Toxoplasma, Plasmodium (malaria) and Eimeria has received considerable attention, but its function was unknown. Official Title Conditions Study Type Study Design Further Details NIAID supported investigators investigated this role usnign parasiticidal treatments against the organelle, called an apicoplast. Molecular…
