The recent discovery of a new organelle in several parasites including Toxoplasma, Plasmodium (malaria) and Eimeria has received considerable attention, but its function was unknown.
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NIAID supported investigators investigated this role usnign parasiticidal treatments against the organelle, called an apicoplast. Molecular analysis revealed how proteins in the apicoplast are encoded in the nucleus, synthesized, and imported via signal peptides. The researchers were able to demonstrate that apicoplast function is directly linked to parasite survival. This work suggests numerous new parasite-specific targets for chemotherapy.
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(Source:NIAID Research Division, Feb 2004)
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