Gastro
01 Jan 2013
Interferon-beta Treatment of Ulcerative Colitis
This study will evaluate the safety and effectiveness of the drug interferon-beta in treating ulcerative colitis and examine the drug’s effect on the immune system. People with ulcerative colitis have increased amounts of inflammatory chemicals (cytokines) made by immune cells in the lining of the colon. Studies have shown that…
Cancer
01 Jan 2013
Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug or combining radiation therapy with chemotherapy may kill more tumor cells. It is not yet known whether fluorouracil and mitomycin plus radiation therapy is more…
Gastro
01 Jan 2013
Research Study in Patients With Severe Ulcerative Colitis
The purpose of the study is to evaluate an intravenous (by injection) investigational medication to treat severe ulcerative colitis refractory to steroid therapy. The research is being conducted at up to 8 clinical research sites in the US and is open to both men and women ages 18 to 70…
Gastro
01 Jan 2013
Immune Regulation in Ulcerative Colitis or Crohn’s Disease
This study will investigate in patients with Crohn’s disease and ulcerative colitis how the body’s immune system controls inflammation in the gastrointestinal tract (stomach and intestines)-specifically, how lymphocytes (a type of white blood cell) function in inflammatory responses. This protocol does not involve any experimental treatments. Official Title Studies of…
Gastro
01 Jan 2013
Treatment of Binge Eating Disorder
This is a multicenter (2 sites) randomized trial evaluating three group treatment models for subjects with binge eating disorder. One model is a cognitive behavior treatment (CBT) group, one is partial self help, and one is self help only. Official Title Conditions – Bulimia- Obesity Study Type Interventional Study…
Gastro
01 Jan 2013
Low-Dose Leptin and the Formerly-Obese
Our previous studies have demonstrated that there is substantial metabolic opposition to the maintenance of an altered body weight. Leptin is a protein secreted by fat cells and the circulating concentrations of leptin are directly proportional to fat mass. Leptin-deficiency is associated with severe obesity in rodents and in humans…
Gastro
01 Jan 2013
Strength Training Following Gastric Bypass for Obesity
We will assess whether undesirable loss of lean tissue following gastric bypass surgery for obesity can be minimized by protein supplementation and exercise training. Official Title Conditions – Obesity Study Type Interventional Study Design Treatment, Randomized, Open Label, Active Control, Factorial Assignment, Efficacy Study Further Details Study Start…
Cancer
01 Jan 2013
Open label study of ONTAK (denileukin diftitox) in previously treated Cutaneous T-cell Lymphoma patients.
The purpose of this study is to provide an opportunity for patients who exhibit progressive disease while receiving placebo on the companion 93-04-11 study to receive ONTAK. It is also designed to determine the effectiveness of ONTAK in CTCL patients whose tumors do not express CD25. Official Title A multicenter…
Cancer
01 Jan 2013
Genetic Study of Young Patients With Colorectal Cancer
RATIONALE: Identifying genemutations (microsatellite instability) may allow doctors to plan effective treatment for patients who develop colorectal cancer at an early age. Official Title Genetic Study of the Prognostic Significance of Microsatellite Instability in Patients With Early Age-of-Onset Stage I-III Colorectal Cancer Conditions – Colon Cancer- hereditary non-polyposis colon…
