Low-Dose Leptin and the Formerly-Obese

Our previous studies have demonstrated that there is substantial metabolic opposition to the maintenance of an altered body weight. Leptin is a protein secreted by fat cells and the circulating concentrations of leptin are directly proportional to fat mass. Leptin-deficiency is associated with severe obesity in rodents and in humans and the obesity is relieved by leptin administration. These studies examine the hypothesis that some of this metabolic opposition cto the maintenance of an altered body weight can be relieved by restoring circulating concentrations of the hormone leptin to the same range as at usual body weight in subjects who are maintaining a reduced body weight. The basic design of this study is to observe subjects at a 10% reduced body weight and then again at that reduced body weight while receiving physiological leptin supplementation.

Official Title

Effects of Low-Dose Leptin on the Metabolic/Behavioral Phenotypes of the Formerly-Obese

Conditions

-obesity

Study Type

Interventional

Study Design

Treatment, Non-Randomized, Single Blind, Uncontrolled, Single Group Assignment, Safety Study

Further Details

Study Start

Eligibility & Criteria

Ages Eligible for Study: 19 Years – 45 Years, Genders Eligible for Study: Both Accepts Healthy VolunteersCriteria Healthy

Total Enrolment

25

Contact Details

[1] Columbia Presbyterian Medical Center, New York, New York, 10032, United States; Recruiting Michael Rosenbaum, MD