Blood
01 Jan 2013
Induction of Stable Chimerism for Sickle Cell Anemia
To investigate a modified hematopoeitic cell transplantation (HCT) procedure for sickle cell disease that significantly reduces the toxicity of HCT, yet retains its therapeutic benefit. To investigate a modified hematopoeitic cell transplantation (HCT) procedure for sickle cell disease that significantly reduces the toxicity of HCT, yet retains its therapeutic benefit.
Cancer
01 Jan 2013
Chemotherapy and Radiation Therapy in Treating Infants With Brain Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining radiation therapy with chemotherapy may kill more tumor cells. RATIONALE: Drugs used in chemotherapy use different ways to stop tumor…
Cancer
01 Jan 2013
XK469 in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.PURPOSE: Phase I trial to study the effectiveness of XK469 in…
Heart
01 Jan 2013
EVEREST: Efficacy of Vasopressin antagonism in hEart failuRE: outcome Study with Tolvaptan
The purpose of this study is to compare the effectiveness of tolvaptan or placebo in adults with worsening congestive heart failure (CHF). The purpose of this study is to compare the effectiveness of tolvaptan or placebo in adults with worsening congestive heart failure (CHF). Condition: – Congestive Heart FailureStudy Type:…
Neurology
01 Jan 2013
Prevention of Alzheimer’s Disease by Vitamin E and Selenium (PREADVISE)
The Prevention of Alzheimer’s Disease by Vitamin E and Selenium (PREADVISE) prevention trial is an important addition to the Selenium and Vitamin E Cancer Prevention Trial (SELECT). As a prevention trial, PREADVISE is trying to find out if taking selenium and/or Vitamin E supplements can help to prevent memory loss…
Cancer
01 Jan 2013
“REDUCE” – A Clinical Research Study To Reduce The Incidence Of Prostate Cancer In Men Who Are At Increased Risk
Purpose This 4-year study will compare how safe and effective an oral investigational medicine is (compared to placebo) in preventing the development of prostate cancer in men that are defined by the study entrance criteria as being at an increased risk for prostate cancer. Study visits to the clinic…
Lungs
01 Jan 2013
Inhaled NO in Prevention of Chronic Lung Disease
Purpose To test the hypothesis that low-dose inhaled nitric oxide administered to preterm infants who continue to require mechanical ventilation at 14 days of age will reduce the incidence of chronic lung disease. Purpose To test the hypothesis that low-dose inhaled nitric oxide administered to preterm infants who continue…
Blood
01 Jan 2013
BEAM Trial
Purpose As many more premature infants survive, the numbers of these infants with health problems also has increased. The rate of cerebral palsy in extremely premature infants is approximately 20%. Magnesium sulfate, the most commonly used drug in the US used to stop premature labor may prevent CP. This…
Infections
01 Jan 2013
Garlic in hyperlipidemia caused by HAART
This is a double-blind randomized placebo controlled trial to test the use of garlic to lower cholesterol and triglycerides in hyperlipidemic HIV-infected individuals who are being treated with highly active antiretroviral therapy (HAART). The garlic will be administered as enteric-coated tablets and in two escalating dosages. Condition: –…
