Infections
01 Jan 2013
Anti-HIV Drug Regimens With or Without Protease Inhibitors and Drug Level Monitoring in HIV Infected Adolescents
Purpose This study will compare the effectiveness of anti-HIV drug regimens with or without a protease inhibitor (PI) in HIV infected adolescents. It will also determine if monitoring drug levels and adjusting the dose as necessary improves the effectiveness of these regimens. Purpose This study will compare the effectiveness…
Infections
01 Jan 2013
OPTIMA (Options in Management with Anti-Retrovirals)
Purpose This ‘pragmatic’ trial is a 2X2 open randomized study of patients in advanced HIV disease who have failed on conventional HAART (Highly Active Antiretroviral Therapy) regimens including all three classes of anti-HIV drugs. The first randomization will allocate patients to an intended 3-month antiretroviral drug-free period (ARDFP) or…
Mental Health
01 Jan 2013
Preliminary Human Trial of NPI-028
This research will determine whether the Chinese herbal medicine (NPI-028) can make a significant contribution to the management of withdrawal and to follow-up treatment aimed at preventing or managing relapse in both women and men alcoholics. The herbal preparation has been used historically in the treatment of alcohol intoxication and…
Mental Health
01 Jan 2013
Glycine and D-Cycloserine in Schizophrenia
The purpose of this study is to compare the effects of D-cycloserine and glycine for treating negative symptoms (such as loss of interest, loss of energy, loss of warmth, and loss of humor) which occur between phases of positive symptoms (marked by hallucinations, delusions, and thought confusions) in schizophrenics. The…
Heart
01 Jan 2013
WARCEF (Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction)
The purpose of this study is to determine which of two treatments, Warfarin or aspirin, is better for preventing death and stroke in patients with poor heart function. The purpose of this study is to determine which of two treatments, Warfarin or aspirin, is better for preventing death and stroke…
Heart
01 Jan 2013
ARISE (Aggressive Reduction of Inflammation Stops Events)
To assess the safety and efficacy of AGI-1067, as compared to placebo, in the treatment of vascular inflammation and atherosclerosis by assessing the reduction in cardiovascular events. To assess the safety and efficacy of AGI-1067, as compared to placebo, in the treatment of vascular inflammation and atherosclerosis by assessing the…
Heart
01 Jan 2013
BARI 2D
The BARI 2D (Bypass Angioplasty Revascularization Investigation in Type 2 Diabetics) trial is a multicenter study that uses a 2×2 factorial design, with 2800 patients being assigned at random to initial elective revascularization with aggressive medical therapy or aggressive medical therapy alone with equal probability, and simultaneously being assigned at…
Lungs
01 Jan 2013
Efficacy of QVAR vs Flovent Diskus on Small Airways in Poorly Controlled Asthmatic Adolescents/Adult Patients
Purpose The primary objective of this study is to evaluate the effect of Beclomethasone dipropionate HFA on small airways compared to Fluticasone propionate powder for inhalation administered twice daily to poorly controlled asthmatics. Purpose The primary objective of this study is to evaluate the effect of Beclomethasone dipropionate HFA…
Lungs
01 Jan 2013
The Genetics of Environmental Asthma
Purpose In this project, we hypothesize that polymorphisms of genes expressed by the airway epithelia in asthmatics following specific airway challenges predispose individuals to the development of asthma. To test this hypothesis, we plan to identify the genes that are differentially expressed by airway epithelial cells following challenge with…
