Bone
01 Jan 2013
Study of Arthritis and Related Conditions
The purpose of this study is to learn more about the causes of rheumatoid arthritis, juvenile rheumatoid arthritis and related conditions and the course of these diseases. Patients in this study will not receive treatment, but may be offered participation in a treatment protocol if an appropriate study is available.
Bone
01 Jan 2013
Literacy in Arthritis Management
This study will test a new patient education program designed for people who do not read well. It will also look at how poor reading skills affect a person’s health and how people who do not read well learn best. We will randomly assign patients who have a rheumatic condition…
Blood
01 Jan 2013
Study of Clotrimazole and Hydroxyurea in Patients With Sickle Cell Syndromes
OBJECTIVES: Determine the effectiveness of the combined use of clotrimazole and hydroxyurea on a specific panel of red cell characteristics in patients with sickle cell syndromes. OBJECTIVES: Determine the effectiveness of the combined use of clotrimazole and hydroxyurea on a specific panel of red cell characteristics in patients with sickle…
Blood
01 Jan 2013
Evaluation of Hydroxyurea Plus L-arginine or Sildenafil to Treat Sickle Cell Anemia
Patients with sickle cell disease have abnormal hemoglobin (the protein in red blood cells that carries oxygen to the body). This abnormality causes red blood cells to take on a sickle shape, producing disease symptoms. Fetal hemoglobin, a type of hemoglobin present in fetuses and babies, can prevent red cells…
Lungs
01 Jan 2013
Ozone and Rhinovirus-Induced Disease in Asthmatics
In the U.S., morbidity associated with human rhinovirus (RV) infection represents a major health problem. In asthmatics, up to 80% of asthma exacerbations are associated with upper respiratory infections. Despite evidence that environmental oxidant pollutants, such as ozone, may increase the severity of viral disease, the mechanisms underlying such an…
Lungs
01 Jan 2013
Effect of Ventilation-Feedback Training on Exercise Performance in COPD
The primary objective of the study is to determine whether individuals with Chronic Obstructive Pulmonary Disease (COPD) who complete ventilation-feedback training combined with a moderately-high intensity exercise and upper body strength program will demonstrate significantly longer exercise duration on a constant work rate treadmill test when compared to subjects who…
Lungs
01 Jan 2013
Role of Role of Genetic Factors in the Development of Lung Disease
This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease. Official Title Role of Genetic Factors in the Pathogenesis of Lung Disease Conditions –…
Lungs
01 Jan 2013
Sample Collections from the Airways of Asthmatic Patients
Fiberoptic bronchoscopy is a procedure which involves passing a pencil-thin tube into the lung in order to collect fluid and cells from the airways. Fiberoptic bronchoscopy can collect cells from the walls of airways by gently brushing them (bronchial brushing). In addition, squirting small amounts of sterile water in to…
Lungs
01 Jan 2013
Nasal Irritation Study
This study seeks to document differences in nasal irritant sensitivity within the population. We are interested in knowing whether age, gender, and allergy status (nasal allergies) predict nasal irritant sensitivity. This is important in understanding symptom reporting patterns in air pollution situations (particularly in so-called “problem buildings”), as well as…
