Research and Trials

Bone 01 Jan 2013

Effects of Arzoxifene on Bone Fractures and Incidence of Breast Cancer

The purpose of this trial is to study: – Effects of arzoxifene on bone fractures and bone mass. – Effects of arzoxifene on getting breast cancer. – Effects of arzoxifene on certain types of cardiovascular events, such as heart attack and stroke. – Effects of arzoxifene that…

Research and Trials 01 Jan 2013

A Randomized, Open-Label, Comparative Evaluation Of Conversion From Calcineurin Inhibitor Treatment To Sirolimus (Rapamune) Treatment versus Continued Calcineurin Inhibitor Treatment In Liver Allograft Recipients Undergoing Maintenance Therapy

To determine the effect of conversion from calcineurin inhibitor to sirolimus (Rapamune) treatment on kidney function. This study will also evaluate the safety and efficacy of the conversion of therapies. Official Title Conditions – Liver Transplantation- Hepatic Transplantation Study Type Interventional Study Design Treatment, Randomized, Open Label, Safety/Efficacy Study…

Hormones 01 Jan 2013

Reduction in the Occurrence of Center-Threatening Diabetic Macular Edema

The purpose of this study is to determine if ruboxistaurin can help slow the worsening of an eye disease called macular edema in patients with diabetes. Official Title Conditions Diabetic Retinopathy Study Type Interventional Study Design Treatment Further Details Study Start Eligibility & Criteria Inclusion Criteria:- You must have…

Infections 01 Jan 2013

Entecavir for Subjects with Chronic Hepatitis B Infection: An Early Access Program

The purpose of this clinical research study is to provide entecavir to subjects with chronic Hepatitis B infection who have failed or who have demonstrated intolerance of marketed therapies or for those in whom use of these agents is contraindicted and that have no other available treatment options. Official Title…

Cancer 01 Jan 2013

Combination Chemotherapy With or Without Rituximab in Treating Patients With Relapsed Non-Hodgkin’s Lymphoma

Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as rituximab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. It is not yet known whether chemotherapy is…

Cancer 01 Jan 2013

Trial of PI-88 with Docetaxel in Advanced Non-Small-Cell Lung Cancer (NSCLC)

PI-88 is a new experimental drug that inhibits tumour growth by reducing the formation of new blood vessels into tumours. Docetaxel is a standard second-line treatment offered to patients with non-small-cell lung cancer who havenât responded to first-line therapies (platinum-based drugs or radiotherapy). Of this group of patients, only 20%…

Heart 01 Jan 2013

Evaluation of Intravenous Levosimendan Efficacy in the Short Term Treatment of Decompensated Chronic Heart Failure.

The purpose of this study is to evaluate the efficacy of a 24-hour infusion of levosimendan compared with placebo in the treatment of decompensated chronic heart failure. Official Title Evaluation of Intravenous Levosimendan Efficacy in the Short Term Treatment of Decompensated Chronic Heart Failure. Conditions Heart Failure, Congestive Study Type…

Bone 01 Jan 2013

International Registry for Severe Chronic Neutropenia

Document the clinical course of severe chronic neutropenia (SCN). II. Monitor and assess long term safety of primary treatment in SCN patients in the United States, Canada, Europe, and Australia. III. Study the incidence and outcome of adverse events such as osteoporosis, splenomegaly, cytogenetic abnormalities, myelodysplastic syndrome, and leukemia. IV.