Infections
01 Jan 2013
Arginine Malaria Trial: Study of Adjunctive Arginine in Falciparum Malaria
This study will examine the safety and effect of escalating doses of arginine in falciparum malaria. It will determine whether arginine can increase NO production and have an effect on NO-dependent physiological measurements. The hypothesis is that arginine: will be safe in falciparum malaria; will return plasma arginine concentration to…
Children's health
01 Jan 2013
Study Evaluating Safety & Immunogenicity of rLP2086 Meningitis Vaccine in Adolescents
Study to evaluate the safety of an investigational meningitis vaccine and the immune response to it in adolescents Official Title A Randomized, Observer-Blinded, Parallel-Group, Active-Control, Phase 1/2 Trial of the Safety, Immunogenicity, and Tolerability of 20 micrograms, 60 micrograms, and 200 micrograms of Meningococcal Group B rLP2086 Vaccine in Healthy…
Cancer
01 Jan 2013
Study to Evaluate the Efficacy of the Human Papillomavirus Vaccine in Healthy Adult Women of 26 Years of Age and Older.
This study will evaluate the immune responses, safety and efficacy of the investigational HPV vaccine in women who are 26 years of age or older. Infection with human papilloma virus (HPV) has been clearly established as the central cause of cervical cancer. Official Title A Study to Evaluate the Safety,…
Research and Trials
01 Jan 2013
Antiviral Activity of Entecavir in Patients Receiving Liver Transplant Due to Chronic Hepatitis B Virus Infection
The purpose of this clinical research study is to learn if the study drug entecavir will prevent the recurrence of hepatitis B virus in subjects who receive an orthotopic liver transplant (OLT). Official Title Study of the Antiviral Activity of Entecavir in Patients Receiving Liver Transplant Due to Chronic Hepatitis…
Research and Trials
01 Jan 2013
Study of a Pandemic Influenza Vaccine in healthy adults
The avian influenza H5N1 virus strain is the leading candidate to cause the next avian influenza pandemic. This study will test the safety and immunogenicity of a H5N1 pandemic influenza vaccine in healthy adults. Official Title Phase Ia Study of a Pandemic Influenza Vaccine Conditions Avian Influenza Study Type Interventional…
Research and Trials
01 Jan 2013
The Pharmacokinetics of Double Boosted Protease Inhibitors in Antiretroviral-Naive HIV-1 Infected Patients
Treatment with only protease inhibitors might benefit HIV patients. Laboratory data have shown that the combination of saquinavir with lopinavir and ritonavir may a good regimen. This study will explore this idea. Official Title Pharmacokinetics of and Rate of HIV-1 RNA Decline in ARV-Naive HIV-1 Infected Patients Treated With Low-…
Research and Trials
01 Jan 2013
Sensory Cues for Freezing in Parkinson’s Disease
The purpose of this study is (1) to determine if patient triggered sensory (auditory, visual and tactile) cues can help treat freezing of gait in Parkinson’s disease, and (2) to assess if unexpected (randomized) cues are more effective than anticipated ones. Official Title Effect of Randomized Patient-Triggered Sensory Cues for…
Research and Trials
01 Jan 2013
A Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-583 in Subjects With Postherpetic Neuralgia (PHN)
The purpose of the study is to assess the safety and ability of TAK-583 to relieve pain in subjects with PHN, compared with placebo. Official Title A Phase 2, Double Blind, Placebo Controlled, Dose-Ranging Study in Subjects With Postherpetic Neuralgia (PHN) to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of…
Research and Trials
01 Jan 2013
Sympathetic Activity in Individuals With the Metabolic Syndrome: Benefits of Lifestyle Interventions
An abdominal distribution of fat is associated with the greatest heart disease risk, because commonly, several risk factors of metabolic origin (high blood pressure, unfavourable cholesterol profile, elevated blood sugar, impaired insulin action) cluster in these individuals. When this occurs the condition is called the metabolic syndrome (MetS). The cause…
