Blood
01 Jan 2013
GM-CSF Vaccinations After Allogeneic Blood Stem Cell Transplantation in Patients With Advanced Myeloid Malignancies
The purpose of this study is to investigate whether the addition of a vaccine after participants reduced intensity transplant will be safe and beneficial. The vaccine used in this trial, called GVAX, will be made from the participants own leukaemia cells, and will be given between 1-4 months after transplant.
Blood
01 Jan 2013
Study to Determine the Effect and Safety of an Oral Janus Kinase 2 (JAK2)-Inhibitor in Patients with Multiple Myeloma
The purpose of this study is to determine clinical efficacy and safety of INCB018424, a small molecule Janus kinase (JAK) inhibitor, in patients with refractory or relapsed multiple myeloma. Official Title A Phase 2, Two Stage, Open-Label, Clinical Trial to Determine the Therapeutic Effect and Safety of an Oral JAK2-Inhibitor…
Blood
01 Jan 2013
Intravenous Iron in Patients With Anaemia of Chronic Kidney Disease
The objective of this study is the evaluation of the efficacy and safety of intravenous iron sucrose in anaemic patients with chronic kidney disease not on renal replacement therapy. Official Title Open Randomized Phase IV Study on Intravenous Iron in Anemic Patients With Chronic Kidney Disease. Conditions Chronic…
Blood
01 Jan 2013
Treatment of Deficient Subclass or Anti-Polysaccharide Antibody
There is no consensus on the treatment of patients with recurrent infections and isolated immunoglobulin G (IgG)-subclass deficiency and/or selective antipolysaccharide antibody deficiency. Therefore, the Dutch Inter University Working Party will start a study in which the treatment with antibiotics is compared with intravenous immunoglobulin therapy with respect to clinical…
Blood
01 Jan 2013
Pesticides in the Households of Healthy Volunteers and Young Patients With Leukaemia
Rationale: Learning about pesticides in the households of young patients with leukaemia and in the households of healthy volunteers may help scientists better understand the risk of leukaemia.Purpose: This epidemiology study is identifying environmental factors related to the risk of leukaemia in the households of healthy volunteers and in the…
Blood
01 Jan 2013
Characteristics of Blood-Brain Barrier Permeability in Neurological Patients
The main goal of the present study is to challenge the hypothesis that blood-brain barrier disruption following brain injury increases the risk for long-term disability, development of brain dysfunction, epileptic seizures and neuroanatomical alterations. Official Title Blood-Brain Barrier Permeability in Neurological Patients: Anatomical, Neurophysiological, and Clinical Characteristics. Conditions Traumatic…
Blood
01 Jan 2013
Iron Sucrose in Stage 3/4 Kidney Disease
Blood
01 Jan 2013
Sequestration of Platelets Prior to Bypass Reduces Bleeding After Cardiac Surgery
Excessive bleeding is common after cardiac surgery. This may result in patients receiving a blood transfusion or suffering the life-threatening complication of cardiac tamponade. Tamponade is when excessive bleeding compresses the heart and prevents it from pumping properly. A major reason for the bleeding is the damage done to platelets…
Cancer
01 Jan 2013
Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema
The purpose of this study is to assess the efficacy and safety of Icatibant, a bradykinin antagonist in the treatment of acute cutaneous and/or abdominal attacks in patients with hereditary angioedema (HAE). Official Title Randomised, Double Blind, Placebo-Controlled, Multicenter Study of a Subcutaneous Formulation of Icatibant for the Treatment of…
