Lungs
01 Jan 2013
Randomised Study of a Simple Weight Loss Program for Obese Patients With Obstructive Sleep Apnoea
The purpose of the study is to determine if weight loss interventions aimed at lifestyle modification (dietary education, food diary pedometer) result in weight loss in patients with mild-moderate obstructive sleep apnoea (OSA) when compared to usual patient care. The secondary purpose of the study is to determine if the…
Hormones
01 Jan 2013
Effect of Growth Hormone on Insulin Signaling in Muscle Tissue
The purpose of this study is to examine the effects of a physiological bolus of growth hormone on insulin signaling pathways in muscle tissue in healthy lean men. Official Title The Effect of a Physiological Bolus of Growth Hormone (GH) on Insulin Signaling Pathways in Muscle Tissue From Healthy Adults…
Hormones
01 Jan 2013
Thyroxine Titration Study
The aim of the study is to examine the effects of fine titration of thyroxine dosage on symptoms of hypothyroidism, wellbeing and quality of life. The hypothesis is that symptoms of hypothyroidism, wellbeing and quality of life will be improved in thyroxine-treated subjects when serum thyrotropin (TSH) is suppressed and/or…
Hormones
01 Jan 2013
Trial of Growth Hormone Therapy in Paediatric Crohn’s Disease
The purpose of this study is to determine whether taking a growth hormone (GH) drug called somatropin causes the intestine of a person with Crohn’s disease (CD) to heal faster when compared to a person with Crohn’s disease that does not receive growth hormone drug. Official Title A Phase II…
Hormones
01 Jan 2013
Jugular Vein Sampling for Hormone Levels for the Diagnosis of Cushing Syndrome
Patients with Cushing’s disease have hormone producing tumours in their pituitary gland. Often these tumours are so small they cannot be detected by magnetic resonance imaging (MRI). The inferior petrosal sinuses are small veins that drain the blood from the pituitary gland. By taking a small sample of blood from…
Hormones
01 Jan 2013
PaTH Study: Parathyroid Hormone and Alendronate for Osteoporosis
This 2-year study will test the effectiveness of combining parathyroid hormone (PTH) and alendronate for treating osteoporosis in postmenopausal women. Alendronate is a drug used to treat osteoporosis and primarily prevents bone loss, whereas PTH increases bone formation. We will treat the study participants either with PTH and alendronate, alendronate…
Hormones
01 Jan 2013
Efficacy and Safety of an Oral Growth Hormone Drug in the Treatment of Fibromyalgia
This is a 24-week, randomised, double-blind, placebo-controlled, trial to evaluate the safety, tolerability and efficacy of an orally administered growth hormone stimulating drug, (code named MK-0677) in the treatment of female subjects with primary fibromyalgia. The basis for this study is the observation that many fibromyalgia patients are growth hormone…
Hormones
01 Jan 2013
Ghrelin, Growth Hormone and Cortisol Interaction in Growth Hormone Deficient Patients
In growth hormone deficient patients: Determination of endogenous circulating ghrelin levels, ghrelin effects on insulin sensitivity, appetite, energy metabolism, and signal transduction in fat and muscle. Official Title Effects of Acute Ghrelin Infusion to Growth Hormone Deficient Adults: Growth Hormone and Cortisol Interaction. Conditions Hypopituitarism Study Type Interventional Study…
Bone
01 Jan 2013
Effect of Growth Hormone on Bone Metabolism in Anorexia Nervosa
Decreased bone strength is a serious medical problem present in many women with Anorexia Nervosa, or disordered eating. Women with weaker bones are more likely to suffer broken bones than women with normal bone strength. We are investigating whether a hormone that is naturally produced by the human body, called…
