Ghrelin, Growth Hormone and Cortisol Interaction in Growth Hormone Deficient Patients

In growth hormone deficient patients: Determination of endogenous circulating ghrelin levels, ghrelin effects on insulin sensitivity, appetite, energy metabolism, and signal transduction in fat and muscle.

Official Title

Effects of Acute Ghrelin Infusion to Growth Hormone Deficient Adults: Growth Hormone and Cortisol Interaction.

Conditions

•  Hypopituitarism

Study Type

Interventional

Study Design

Treatment, Randomised, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Placebo Control, Crossover Assignment, Pharmacokinetics/Dynamics Study.

Further Details

Primary Outcome Measures:

• Endogenous serum ghrelin levels

Secondary Outcome Measures:

• Insulin sensitivity, appetite, metabolism, intracellular signal transduction

Study Start

October 2005

Eligibility & Criteria

• Ages Eligible for Study: 18 years to 60 years
• Genders Eligible for Study: Both
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Age between 18 and 60 years
• Verified hypopituitarism
• Unchanged substitution treatment through 3+ months
• Unchanged additional medical treatment
• Oral and written informed consent

Exclusion Criteria:

• Age below 18 or above 60 years
• Diabetes mellitus
• Body mass index > 30
• Fasting hypoglycaemia
• Convulsions
• Allergy to trial products

Total Enrolment

8

Contact Details

Jens Otto L Jorgensen, DrMedSci
Aarhus University Hospital

Location:

Aarhus University Hospital   
Aarhus
Denmark, 8000