Effect of Growth Hormone on Insulin Signaling in Muscle Tissue

The purpose of this study is to examine the effects of a physiological bolus of growth hormone on insulin signaling pathways in muscle tissue in healthy lean men.

Official Title

The Effect of a Physiological Bolus of Growth Hormone (GH) on Insulin Signaling Pathways in Muscle Tissue From Healthy Adults

Conditions

• Insulin Resistance

Study Type

Interventional

Study Design

Basic Science, Randomised, Single Blind (Subject), Placebo Control, Factorial Assignment.

Further Details

Primary Outcome Measures:

• PI3-kinase activity i muscle tissue

Secondary Outcome Measures:

• Growth Hormone Signaling Proteins in Muscle Tissue and other Insulin Signaling Proteins in Muscle Tissue.

Study Start

May 2007

Eligibility & Criteria

Eligibility:

• Ages Eligible for Study: 18 Years to 30 Years
• Genders Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Male
• Healthy
• Age between 18 and 30 years
• BMI ≤ 26

Exclusion Criteria:

• Known present disease including diabetes mellitus
• BMI > 26
• Uses any medication
• Consumes > 21 units of alcohol per week

Total Enrolment

8

Contact Details

Denmark Department M (endocrinology and diabetes)    
Aarhus, Denmark, 8000