Heart
01 Jan 2013
Lipitor In The Prevention Of Stroke, For Patients Who Have Had A Previous Stroke (SPARCL)
To determine whether Lipitor reduces stroke, compared to placebo in patients who have had a previous stroke or transient ischemic attack. Official Title A Double-Blind, Randomized, Placebo- Controlled Study Of Atorvastatin As Prevention Of Cerebrovascular Events In Patients With A Previous Transient Ischemic Attack (TIA) Or Stroke Conditions Stroke,…
Cancer
01 Jan 2013
Combination Chemotherapy Plus Radiation Therapy in Treating Children With Newly Diagnosed Brain Stem Glioma
Phase I trial to study the effectiveness of vincristine plus etoposide and radiation therapy in treating children who have newly diagnosed brain stem glioma.Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor…
Children's health
01 Jan 2013
Study Evaluating Safety & Immunogenicity of rLP2086 Meningitis Vaccine in Adolescents
Study to evaluate the safety of an investigational meningitis vaccine and the immune response to it in adolescents Official Title A Randomized, Observer-Blinded, Parallel-Group, Active-Control, Phase 1/2 Trial of the Safety, Immunogenicity, and Tolerability of 20 micrograms, 60 micrograms, and 200 micrograms of Meningococcal Group B rLP2086 Vaccine in Healthy…
Cancer
01 Jan 2013
Brain Metastases Study
Purpose- Comparison of radiotherapy fractionation schemes for brain metastasis. Official Title To Determine Which of Two Radiotherapy Brain Fractionation Schemes is Superior in the Treatment of Brain Metastases Conditions Study Type Interventional Study Design Treatment, Randomized, Open Label, Dose Comparison, Parallel Assignment, Efficacy Study Further Details Primary Outcomes: Control of…
Blood
01 Jan 2013
Safety of NXY-059 for the Treatment of Patients who have Suffered from a Stroke
This study will determine if NXY-059 is safe in patients with an acute stroke caused by bleeding in the central nervous system. Official Title CHANT (Cerebral Hemorrhage And NXY Treatment) A Double-Blind, Randomized, Placebo-Controlled, Parallel group, Multicenter, Phase IIb Study to Assess the Safety and Tolerability of Intravenous Infusion of…
Neurology
01 Jan 2013
Comprehensive Program to Improve Reading and Writing Skills in At-Risk and Dyslexic Children
This project is evaluating programs to improve reading and writing skills in children who have or are at risk for having reading disabilities. The project focuses on children who are at-risk for low achievement in school and on children with dyslexia. Official Title Learning Disabilities: Links to Schools and Biology…
Cancer
01 Jan 2013
Study of SU011248 in Patients with Neuroendocrine Tumors
The primary objective of the study is to determine the efficacy and safety of SU011248 as a treatment for patients with advanced unresectable neuroendocrine tumor; however, CURRENTLY ONLY RECRUITING FOR PATIENTS SPECIFICALLY WITH PANCREATIC ISLET CELL TUMORS. Official Title Phase II Study of SU011248 in Patients with Neuroendocrine Tumors; however,…
Neurology
01 Jan 2013
Prevention of cognitive decline in Alzheimer’s disease by ingested interferon alpha
In this phase I-II parallel design, randomized, double-blind clinical trial we will determine if 3,000 or 30,000 units ingested hrIFN-a prevents deterioration of cognitive functioning in patients with dementia of Alzheimer’s type (AD) and whether ingested hrIFN-a treatment decreases acute phase reactants and pro-inflammatory cytokine IL-6 in mild to moderate…
Lungs
01 Jan 2013
Safety and Efficacy Study of CEP-10953 in the Treatment of Excessive Sleepiness Associated with Narcolepsy
The primary objective of this study is to determine whether treatment with CEP-10953 is more effective than placebo treatment for patients with excessive sleepiness associated with narcolepsy by measuring mean sleep latency from the Maintenance of Wakefulness (MWT) (20-minute version)(average of 4 naps at 0900, 1100, 1300, and 1500) and…
