Neurology
01 Jan 2013
Biological Markers in Parkinson’s Disease
This study will identify abnormalities of a protein called alpha synuclein that is found in the brain of patients with Parkinson’s disease and related disorders to see if it can serve as a disease marker. There is currently no treatment that will cure or delay progression of Parkinson’s disease. Thus,…
Mental Health
01 Jan 2013
Efficacy and Safety of Aricept in the Treatment of Severe Alzheimer’s Disease
Donepezil hydrochloride (Aricept) has been approved to treat symptoms associated with mild to moderate Alzheimer’s disease (AD). Aricept has been shown to improve the memory and thinking abilities, activities of daily living and global function in patients. The purpose of the study is to further investigate the effectiveness and safety…
Neurology
01 Jan 2013
Brain Study of Patients with Frontal Lobe Dementia and Parkinsonian Disorders
The Cognitive Neuroscience Section of the National Institute of Neurological Disorders and Stroke proposes to continue its cross-sectional and longitudinal studies of cerebral metabolism in frontal lobe dementias and atypical basal ganglia disorders. These studies include repeated assessments of neuropsychological and brain anatomical and metabolic function in subjects with these…
Neurology
01 Jan 2013
Diagnosis and History Study of Patients with Different Neurological Conditions
The goal of this study is to diagnose and follow patients with disorders of movement control. Patients participating in this study will undergo routine laboratory tests and examinations in order to monitor their condition. Official Title Diagnosis and Natural History Protocol for Patients with Different Neurological Conditions Conditions – Nervous…
Neurology
01 Jan 2013
Effect of Fluoxetine (Prozac) on Domestic Violence
This study will evaluate whether fluoxetine (Prozac), used together with traditional psychotherapy, can reduce aggression in people who are physically violent towards their spouses or significant others. Treatment for domestic violence has centered on behavioral therapies, such as anger management and self-control exercises. Recent studies have shown that fluoxetine-a drug…
Neurology
01 Jan 2013
Magnetic Resonance Spectroscopy to Evaluate Tourette’s Syndrome
This study will use magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) of the brain to try to gain a better understanding of the disease process in Tourette’s syndrome, a neuropsychiatric disorder characterized by motor and vocal tics. Tourette’s syndrome is also associated with behavioral and emotional disturbances, including…
Mental Health
01 Jan 2013
Vitamin E in Aging Persons With Down Syndrome
The goal of this study is to determine the safety and efficacy of the administration of vitamin E, which has been shown to delay the progression of Alzheimer’s disease, in slowing the rate of cognitive/functional decline in older persons with Down syndrome. Official Title Multicenter Vitamin E Trial in Aging…
Neurology
01 Jan 2013
Minocycline in Patients with Huntington’s Disease
This is a study to determine whether treatment with minocycline is safe and tolerable in patients with Huntington’s disease (HD) and whether minocycline reduces symptoms of HD in these patients. Official Title Conditions – Huntington’s Disease Study Type Interventional Study Design Treatment, Randomized, Double-Blind, Placebo Control, Safety/Efficacy Study Further…
Neurology
01 Jan 2013
Droxidopa in Treating Patients With Neurogenic Hypotension
RATIONALE: Neurogenic hypotension is a fall in blood pressure that occurs when one moves from a lying down to a standing position or after eating a meal. It causes one to feel dizzy, light headed, and weak. Neurogenic hypotension is caused by a problem in the part of the nervous…
