Blood
01 Jan 2013
Characteristics of Blood-Brain Barrier Permeability in Neurological Patients
The main goal of the present study is to challenge the hypothesis that blood-brain barrier disruption following brain injury increases the risk for long-term disability, development of brain dysfunction, epileptic seizures and neuroanatomical alterations. Official Title Blood-Brain Barrier Permeability in Neurological Patients: Anatomical, Neurophysiological, and Clinical Characteristics. Conditions Traumatic…
Children's health
01 Jan 2013
An Effectiveness and Safety Study of ‘CONCERTA’ (Methylphenidate Hydrochloride) in the Treatment of Adolescents With Attention Deficit Hyperactivity Disorder
The purpose of this study is to evaluate the safety and effectiveness of CONCERTA (methylphenidate hydrochloride, a central nervous system (CNS) stimulant) versus placebo for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in adolescents. Official Title An Evaluation of the Safety and Effectiveness of CONCERTA (Methylphenidate Hydrochloride), up to…
Infections
01 Jan 2013
Study Evaluating the Safety, Immunogenicity and Tolerability of Meningococcal Group B Vaccine in Healthy Adults
To determine the safety & immunogenicity of a potential vaccine against meningococcal B disease Official Title A Randomized, Placebo-Controlled, Double Blind, Phase 1 Trial of the Safety, Immunogenicity, and Tolerability of Ascending Doses of Meningococcal Group B rLP2086 Vaccine in Healthy Adults Conditions Meningitis, Meningococcal Study Type Interventional Study…
Neurology
01 Jan 2013
Effectiveness Of The Drug GSK189254 In Treating Patients With Narcolepsy
The purpose of this study is to assess the effectiveness and safety of the drug GSK189254 in treating patients with narcolepsy. Official Title An Open Label, Dose Escalation Study With A Double Blind Randomised Placebo Controlled Withdrawal To Examine The Effects Of The Histamine H3 Antagonist GSK189254 In Patients With…
Cancer
01 Jan 2013
Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma
This randomized phase III trial is studying standard-dose radiation therapy to see how well it works compared to reduced-dose craniospinal radiation therapy AND posterior fossa boost radiation therapy to see how well it works compared to tumor bed boost radiation therapy when given together with chemotherapy in treating young patients…
Neurology
01 Jan 2013
Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone Therapy
The purpose of this trial is to determine if thymectomy combined with prednisone therapy is more beneficial in treating non-thymomatous myasthenia gravis than prednisone therapy alone. Official Title A Multi-Center, Single-Blind, Randomized Study Comparing Thymectomy to No Thymectomy in Non-Thymomatous Myasthenia Gravis (MG) Patients Receiving Prednisone Conditions Myasthenia Gravis…
Chronic Pain
01 Jan 2013
Oral Dexamethasone for Treatment of Migraine
The aim of this project is to determine if a single dose of oral dexamethasone at the time of discharge from the ED prevents rebound headache. Official Title Does a Single Oral Dose of Dexamethasone After Successful Emergency Treatment of Migraine Reduce the Incidence or Severity of Rebound Headache Within…
Neurology
01 Jan 2013
Evaluation of Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.
To determine long-term safety and efficacy of pregabalin in patients with partial seizures. Official Title Pregabalin Open-Label Add-On Trial: An Open-Label, Multicenter Follow-On Study to Determine Long-Term Safety and Efficacy in Patients With Partial Seizures. Conditions Seizure Disorder, Partial Study Type Interventional Study Design Treatment, Non-Randomized, Open Label,…
Neurology
01 Jan 2013
Efficacy and Safety of Fingolimod in Patients With Relapsing-Remitting Multiple Sclerosis With Optional Extension Phase (TRANSFORMS)
This study will assess safety, tolerability and efficacy of two doses of oral fingolimod versus interferon Beta-1a to reduce the frequency of relapses in patients with relapsing-remitting multiple sclerosis. Official Title A 12-Month Study Comparing the Efficacy and Safety of Two Doses of Fingolimod Versus Interferon Beta-1a in Patients With…