Lungs
01 Jan 2013
Ozone and Rhinovirus-Induced Disease in Asthmatics
In the U.S., morbidity associated with human rhinovirus (RV) infection represents a major health problem. In asthmatics, up to 80% of asthma exacerbations are associated with upper respiratory infections. Despite evidence that environmental oxidant pollutants, such as ozone, may increase the severity of viral disease, the mechanisms underlying such an…
Lungs
01 Jan 2013
Effect of Ventilation-Feedback Training on Exercise Performance in COPD
The primary objective of the study is to determine whether individuals with Chronic Obstructive Pulmonary Disease (COPD) who complete ventilation-feedback training combined with a moderately-high intensity exercise and upper body strength program will demonstrate significantly longer exercise duration on a constant work rate treadmill test when compared to subjects who…
Lungs
01 Jan 2013
Role of Role of Genetic Factors in the Development of Lung Disease
This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease. Official Title Role of Genetic Factors in the Pathogenesis of Lung Disease Conditions –…
Lungs
01 Jan 2013
Sample Collections from the Airways of Asthmatic Patients
Fiberoptic bronchoscopy is a procedure which involves passing a pencil-thin tube into the lung in order to collect fluid and cells from the airways. Fiberoptic bronchoscopy can collect cells from the walls of airways by gently brushing them (bronchial brushing). In addition, squirting small amounts of sterile water in to…
Lungs
01 Jan 2013
Nasal Irritation Study
This study seeks to document differences in nasal irritant sensitivity within the population. We are interested in knowing whether age, gender, and allergy status (nasal allergies) predict nasal irritant sensitivity. This is important in understanding symptom reporting patterns in air pollution situations (particularly in so-called “problem buildings”), as well as…
Lungs
01 Jan 2013
Study Evaluating the Safety and Efficacy of Infliximab in Subjects with Moderate to Severe Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine the safety and efficacy of infliximab in patients with moderate to severe Chronic Obstructive Pulmonary Disease. Official Title A Phase II, Multicenter, Randomized, Double-blind, Placebo-controlled Parallel Group, Dose Finding Study Evaluating the Safety and Efficacy of Infliximab Administration in Symptomatic Subjects with…
Lungs
01 Jan 2013
Study of the Disease Process of Lymphangioleiomyomatosis
Pulmonary lymphoangioleiomyomatosis (LAM) is a destructive lung disease typically affecting women of childbearing age. Currently, there is no effective therapy for the disease and the prognosis is poor. Official Title Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM) Conditions – Leiomyomatosis- Lung Disease- Pneumothorax- Tuberous Sclerosis Study Type Observational Study…
Lungs
01 Jan 2013
Acute Respiratory Distress Syndrome Clinical Network (ARDSNet)
To assess rapidly innovative treatment methods in patients with adult respiratory distress syndrome as well as those at risk of developing ARDS. To establish a network of interactive Critical Care Treatment Groups (CCTG) to establish and maintain the required infrastructure to perform multiple therapeutic trials that may involve investigational drugs,…
Lungs
01 Jan 2013
Study of Inhaled Nitric Oxide for Preterm Infants
This multicenter trial tests whether inhaled nitric oxide will reduce death or the need for oxygen at 36 weeks postmenstrual age in preterm infants with severe lung disease. Official Title Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure Conditions – Respiratory Distress Syndrome- Infant, premature- Sepsis- Pneumonia-…
