Lungs
01 Jan 2013
Evaluation of various doses of Ro 27-2771 (test drug) in asthmatic patients not treated with inhaled corticosteroids
The purpose of this study is to determine the appropriate dose of Ro 27-2441 (test drug) to be used in future studies, assess the efficacy and safety, and the anti-inflammatory action of the test drug in the treatment of asthmatic patients who are not currently receiving chronic therapy with corticosteroids.
Children's health
01 Jan 2013
Safety and Efficacy Study of Etanercept (Enbrel) In Children with Systemic Onset Juvenile Rheumatoid Arthritis
This study will determine the efficacy of etanercept in children with systemically active systemic onset juvenile rheumatoid arthritis (SOJRA). Official Title Phase 3 Safety and Efficacy Study of Etanercept (Enbrel®) In Children with Systemic Onset Juvenile Rheumatoid Arthritis Conditions Arthritis, Juvenile Rheumatoid Study Type Interventional Study Design Treatment,…
Cancer
01 Jan 2013
Trial of PI-88 with Docetaxel in Advanced Non-Small-Cell Lung Cancer (NSCLC)
PI-88 is a new experimental drug that inhibits tumour growth by reducing the formation of new blood vessels into tumours. Docetaxel is a standard second-line treatment offered to patients with non-small-cell lung cancer who havenât responded to first-line therapies (platinum-based drugs or radiotherapy). Of this group of patients, only 20%…
Lungs
01 Jan 2013
APPLES: Apnea Positive Pressure Long-Term Efficacy Study
To determine the effectiveness of nasal continuous positive airway pressure (CPAP) therapy for the treatment of obstructive sleep apnea syndrome. Official Title – Lung Diseases- Sleep Apnea Syndromes- Sleep Conditions Study Type Interventional Study Design Treatment, Randomized Further Details BACKGROUND: Nasal continuous positive airway pressure (CPAP) therapy is in widespread…
Lungs
01 Jan 2013
OPUS Study: Effect of Roflumilast on exacerbation rate in patients with chronic obstructive pulmonary disease
The purpose of this study is to determine whether roflumilast is effective in the treatment of exacerbations in patients with chronic obstructive pulmonary disease (COPD). Official Title Conditions – Chronic Obstructive Pulmonary Disease Study Type Interventional Study Design Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study Further Details Study…
Lungs
01 Jan 2013
Safety Study of the Aeris Bronchoscopic Lung Volume Reduction (BLVR) System in Patients with Advanced Emphysema
The purpose of this study is to determine whether the Aeris Bronchoscopic Lung Volume Reduction (BLVR) System is safe in patients with advanced emphysema. Official Title A Single-center, Non-blinded, Non-randomized, Non-controlled Phase 1 Trial Assessing the Safety of the Aeris Therapeutics Bronchoscopic Lung Volume Reduction (BLVR) System in Patients with…
Lungs
01 Jan 2013
Segmental Bronchoalveolar Lavage
Bronchoalveolar lavage is a diagnostic and therapeutic procedure conducted by placing a fiberoptic scope into the lung of a patient, and injecting sterile water (saline) into the lung and removing. The sterile water removed contains secretions, cells, and protein from the lower respiratory tract. This sample can be analyzed to…
Lungs
01 Jan 2013
Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to determine whether genetic factors contribute to an individuals risk of developing obstructive lung disease from smoking cigarettes. Official Title Genetic Mechanisms of Chronic Obstructive Pulmonary Disease Conditions – Chronic Obstructive Lung Disease Study Type Observational Study Design Screening, Cross-Sectional, Defined Population, Retrospective Study…
Lungs
01 Jan 2013
Sarcoid Genetic Analysis (SAGA)
To identify sarcoidosis susceptibility genes and to determine how these genes and environmental risk factors interact to cause sarcoidosis. Official Title Conditions – Lung Diseases- Sarcoidosis Study Type Observational Study Design Natural History, Defined Population Further Details BACKGROUND: Sarcoidosis is a rare systemic granulomatous disease that mainly affects…
