Segmental Bronchoalveolar Lavage

Bronchoalveolar lavage is a diagnostic and therapeutic procedure conducted by placing a fiberoptic scope into the lung of a patient, and injecting sterile water (saline) into the lung and removing. The sterile water removed contains secretions, cells, and protein from the lower respiratory tract. This sample can be analyzed to provide more information about possible disease processes going on in the lungs.

Official Title

Conditions

– Healthy- Lung Disease- Pulmonary Fibrosis

Study Type

Observational

Study Design

Screening

Further Details

This protocol will be used to perform BAL, bronchial brushing, and bronchial wall biopsy in normal volunteers. The samples collected during the study will be used to examine biochemical processes in the lung that may contribute to lung disease.This protocol proposes to perform bronchoalveolar lavage, bronchial brushing and bronchial wall biopsy in research volunteers and in patients with pulmonary disease to evaluate the cellular components of normal and diseased lungs. This research study will help to improve our understanding of pathogenic mechanisms in the lung during progression of pulmonary disease.

Study Start

Eligibility & Criteria

Genders Eligible for Study: BothAccepts Healthy VolunteersCriteriaINCLUSION CRITERIAPatients and research volunteers will be accepted for bronchoscopy and bronchoalveolar lavage only if their heath status will not be compromised by the procedure.EXCLUSION CRITERIAPatients or research volunteers with abnormalities that contraindicate, or increase the risk of, fiberoptic bronchoscopy and bronchoalveolar lavage, including a history of allergy to atropine, lidocaine, or other topical anesthetics or premedications; FEV(1) less than 0.8 liters; PaO(2), on supplemental 02, of less than 70 mmHg or PaCO(2) greater than 45 mmHg; presence of uncorrected clotting disorder, uncontrolled hypertension, significant cardiac disease, renal or liver failure; metastatic disease; hematologic disorders such as severe anemia (hemoglobin less than or equal to 7 g/ml), granulocytopenia, or platelet disorders.Patients or research volunteers with a positive serum test for human immunodeficiency virus or hepatitis B or C.Patients or research volunteers who are pregnant or lactating.Patients or research volunteers who are incapable of giving informed consent .

Total Enrolment

9999

Contact Details

[1] National Heart, Lung and Blood Institute (NHLBI), 9000 Rockville Pike, Bethesda, Maryland, US