Infections
01 Jan 2013
Entecavir for Subjects with Chronic Hepatitis B Infection: An Early Access Program
The purpose of this clinical research study is to provide entecavir to subjects with chronic Hepatitis B infection who have failed or who have demonstrated intolerance of marketed therapies or for those in whom use of these agents is contraindicted and that have no other available treatment options. Official Title…
Blood
01 Jan 2013
Effects on the Immune System of Anti-HIV Drugs in Patients Recently Infected with HIV
The purpose of this study is to find out whether these powerful combinations of anti-HIV drugs are safe and effective for use in patients in the early stages of HIV infection and to find out how patients’ immune systems react to HIV and anti-HIV drugs. Doctors generally treat patients in…
Infections
01 Jan 2013
A Comparison of Two Ways to Manage Anti-HIV Treatment (The SMART Study)
The purpose of this study is to compare two ways of using anti-HIV drugs to help health care providers and patients decide how to best use anti-HIV treatments over many years. Many health care providers now treat patients with daily drugs to keep the viral load as low as possible.
Infections
01 Jan 2013
Investigating Severe Acute Respiratory Syndrome (SARS)
Severe Acute Respiratory Syndrome (SARS) is a newly recognized illness that can be fatal. Official Title An Investigation of the Inflammatory Response in Severe Acute Respiratory Syndrome (SARS) Conditions -SARS Virus Study Type Observational Study Design Natural History Further Details The purpose of this study is to better understand SARS…
Infections
01 Jan 2013
Effect of a T-20 Based Anti-HIV Drug Regimen on HIV Reservoirs
Resting CD4 cells are inactive but can become active in the future. HIV replication in the resting cells is so minimal that anti-HIV drugs often fail to eradicate virus in these cells. T-20, also known as enfuvirtide, is a new type of anti-HIV drug called a fusion inhibitor. The purpose…
Infections
01 Jan 2013
An International Study to Evaluate Anti-HIV Therapy Plus Interleukin-2 (rIL-2) in HIV-Positive Patients
The purpose of this study is to see if it is effective to give HIV-positive patients interleukin-2 (rIL-2) in addition to anti-HIV therapy. Patients will be followed over a period of 5 years to study the long-term effects of rIL-2 on their HIV disease progression. Anti-HIV therapy has been very…
Infections
01 Jan 2013
Intrathecal Gemcitibine to Treat Neoplastic Meningitis
Gemcitabine is an investigational drug for treatment of neoplastic meningitis (cancer that has spread to the lining of the brain and spinal cord). The purposes of this study are: to determine the highest dose of gemcitabine, an anti-cancer drug, that can safely be given directly into the spinal fluid…
Infections
01 Jan 2013
Experimental Ebola Vaccine Trial
This study will test the safety of an experimental vaccine developed to protect against Ebola virus infection and to determine if the vaccine induces an immune response to the virus. The Ebola virus causes a disease called Ebola hemorrhagic fever. Symptoms begin with fever and muscle aches and progress to…
Infections
01 Jan 2013
Assessment of valganciclovir in neonates with CMV
Primary: -To determine the pharmacokinetics of ganciclovir following administration of oral valganciclovir syrup in neonates and young infants with symptomatic congenital CMV disease -To identify a dose of valganciclovir to provide comparable ganciclovir plasma concentrations in neonates and young infants with symptomatic congenital CMV disease. Secondary: -To evaluate…
