Infections
01 Jan 2013
Venticute in Patients With Pneumonia or Aspiration of Gastric Contents and Intubation/Ventilation/Oxygenation Impairment
Study to demonstrate that administration of Venticute increases survival of patients with pneumonia or aspiration of gastric contents leading to intubation, mechanical ventilation, and severe oxygenation impairment. Official Title Venticute in Patients With Pneumonia or Aspiration of Gastric Contents Leading to Intubation, Ventilation, and Severe Oxygenation Impairment: A Randomized, Multinational,…
Infections
01 Jan 2013
Arginine Malaria Trial: Study of Adjunctive Arginine in Falciparum Malaria
This study will examine the safety and effect of escalating doses of arginine in falciparum malaria. It will determine whether arginine can increase NO production and have an effect on NO-dependent physiological measurements. The hypothesis is that arginine: will be safe in falciparum malaria; will return plasma arginine concentration to…
Children's health
01 Jan 2013
Study Evaluating Safety & Immunogenicity of rLP2086 Meningitis Vaccine in Adolescents
Study to evaluate the safety of an investigational meningitis vaccine and the immune response to it in adolescents Official Title A Randomized, Observer-Blinded, Parallel-Group, Active-Control, Phase 1/2 Trial of the Safety, Immunogenicity, and Tolerability of 20 micrograms, 60 micrograms, and 200 micrograms of Meningococcal Group B rLP2086 Vaccine in Healthy…
Infections
01 Jan 2013
Study of Viramidine to Ribavirin in Patients with Chronic Hepatitis C Who Are Treatment Naive
The purpose of this study is to determine the safety and effectiveness of viramidine to ribavirin in chronic hepatitis C patients who have never before received treatment. Official Title Randomized, Double-Blind, Multicenter Study to Compare the Safety and Efficacy of Viramidine to Ribavirin in Treatment-Naive Patients With Chronic Hepatitic C…
Infections
01 Jan 2013
Tifacogin for the Treatment of Patients with Severe Community-Acquired Pneumonia
The purpose of this study is to determine whether tifacogin is effective and safe in the treatment of patients with severe community-acquired pneumonia. Official Title Tifacogin (recombinant tissue factor pathway inhibitor) for the Treatment of Patients with Severe Community-Acquired Pneumonia Conditions Pneumonia Study Type Interventional Study Design Treatment Further Details…
Infections
01 Jan 2013
Efficacy and safety of Pegasys plus Copegus in patients with chronic Hepatitis C who are unable to tolerate or who do not respond to 12 weeks of therapy with PEG-Intron plus Rebetol/Ribavirin.
The objective of this study is to investigate if patients with Chronic Hepatitis C virus who were unable to tolerate or did not respond to 12 weeks of PEG-Intron plus Rebetol/Ribavirin therapy can be safely initiated on Pegasys plus Copegus therapy and tolerate and complete a full course (36 to…
Infections
01 Jan 2013
Prophylactic Heparin during Xigris Treatment of High-Risk Severe Sepsis
The purpose of this study is to evaluate the relative efficacy and safety of prophylactic heparin co-administration during Xigris infusion in the treatment of severe sepsis in the adult. Official Title Conditions Sepsis Study Type Interventional Study Design Treatment Further Details Study Start Eligibility & Criteria Inclusion Criteria- Must…
Infections
01 Jan 2013
Linezolid in the Treatment of Subjects with Nosocomial Pneumonia Proven to be due to Methicillin-Resistant Staphylococcus Aureus
Linezolid is the first of a new class of antibiotics with a unique mechanism of action against Methicillin-Resistant Staphylococcus Aureus (MRSA). This is a Phase IV, double-blinded, randomized study for patients with hospital acquired pneumonia proven to be caused by MRSA. Patients will be treated with linezolid or vancomycin for…
Infections
01 Jan 2013
Linezolid in the Treatment of Complicated Skin and Soft Tissue due to Methicillin-Resistant Staphylococcus Aureus
This is a Phase IV randomized, multi-center, open label trial to compare the clinical safety and efficacy of linezolid to vancomycin in the treatment of complicated skin and soft tissue infections due to methicillin-resistant staphylococcus aureus in adult subjects hospitalized for at least one day. Official Title Linezolid in the…
