Gastro
01 Jan 2013
Immune Regulation in Ulcerative Colitis or Crohn’s Disease
This study will investigate in patients with Crohn’s disease and ulcerative colitis how the body’s immune system controls inflammation in the gastrointestinal tract (stomach and intestines)-specifically, how lymphocytes (a type of white blood cell) function in inflammatory responses. This protocol does not involve any experimental treatments. Official Title Studies of…
Gastro
01 Jan 2013
Treatment of Binge Eating Disorder
This is a multicenter (2 sites) randomized trial evaluating three group treatment models for subjects with binge eating disorder. One model is a cognitive behavior treatment (CBT) group, one is partial self help, and one is self help only. Official Title Conditions – Bulimia- Obesity Study Type Interventional Study…
Gastro
01 Jan 2013
Low-Dose Leptin and the Formerly-Obese
Our previous studies have demonstrated that there is substantial metabolic opposition to the maintenance of an altered body weight. Leptin is a protein secreted by fat cells and the circulating concentrations of leptin are directly proportional to fat mass. Leptin-deficiency is associated with severe obesity in rodents and in humans…
Gastro
01 Jan 2013
Strength Training Following Gastric Bypass for Obesity
We will assess whether undesirable loss of lean tissue following gastric bypass surgery for obesity can be minimized by protein supplementation and exercise training. Official Title Conditions – Obesity Study Type Interventional Study Design Treatment, Randomized, Open Label, Active Control, Factorial Assignment, Efficacy Study Further Details Study Start…
Gastro
01 Jan 2013
Free-Living Physical Activity and Energy Expenditure
We have recently validated a new device for measurement of physical activity and found it to detect type, duration and intensity of many types of physical activity at better than 98% accuracy. After further validating this device to determine if it can also accurately assess energy expenditure, we will use…
Gastro
01 Jan 2013
Obesity and Free Fatty Acid Flux
This study, conducted at the National Institutes of Health in Bethesda, Maryland, and at the Mayo Clinic in Rochester, Minnesota, will explore obesity among Caucasians and African-Americans by examining the relationship of resting energy expenditure (REE) to fatty acid flux. REE is the rate the body uses calories while at…
Gastro
01 Jan 2013
Chromium Effects in Impaired Glucose Tolerance
Impaired glucose tolerance(IGT) often precedes Type II diabetes and is a cardiac risk. Chromium (Cr) is an insulin co-factor. This study will investigate the effects of daily Chromium for 6 months at two doses on serum measures of glucose tolerance and endothelial function in adults with IGT. Official Title Conditions…
Gastro
01 Jan 2013
Dietary Macronutrients and Weight Loss
To test the effectiveness for weight loss and weight maintenance of four diets differing in macronutrient composition: moderate in fat (35 percent energy) with two different protein levels (15 percent and 25 percent), and low in fat (20 percent energy), also with 15 percent and 25 percent protein. Official Title…
Gastro
01 Jan 2013
G-CSF to Treat Crohn’s Disease
This study will examine the effectiveness of G-CSF in treating patients with Crohn’s disease-a long-term recurring inflammation of the small and large intestine. Patients may have swelling and bleeding of the intestinal lining, which can lead to infection and abdominal pain, weight loss, fever, diarrhea, bloody stools, fistula (connections between…
