Bone
01 Jan 2013
Cytokine Gene Polymorphisms in Bone Marrow Failure
This study will examine whether cytokine gene polymorphisms affect the progression or response to therapy of bone marrow failure disorders. Cytokine genes instruct cells to produce proteins called cytokines that influence immune system response. As with many genes, the cytokine genes differ slightly from person to person. These differences are…
Bone
01 Jan 2013
Study of Daily Pentoxifylline as a Rescue Treatment in Duchenne Muscular Dystrophy
The purpose of this study is to see if male children with Duchenne muscular dystrophy (DMD) have changes in strength when given the drug Pentoxifylline as a rescue treatment. A total of 64 subjects are expected to participate through all other centers of the Cooperative International Neuromuscular Research Group (CINRG)…
Bone
01 Jan 2013
Efficacy and Safety of Zoledronic Acid for the Treatment of Osteoporosis in Men
The goal of this study is to determine the effectiveness and safety of an annual intravenous treatment of zoledronic acid for the treatment of osteoporosis in men. All patients will receive calcium and vitamin D supplements. Official Title Efficacy and Safety of Zoledronic Acid for the Treatment of Osteoporosis in…
Bone
01 Jan 2013
Abatacept in the Treatment and Prevention of Active Systemic Lupus Erythematosus (SLE) Flares in Combination With Prednisone
The purpose of this clinical research study is to learn whether Abatacept can treat and prevent lupus flares; specifically, active lupus flares in at least one of three organ systems: skin (discoid lesions), inflammation of the lining of the heart (pericarditis), or inflammation of the lining of the lung (pleuritis/pleurisy);…
Bone
01 Jan 2013
A Study of Monthly Risedronate for Osteoporosis
The purpose of this trial is to study the efficacy of a single-dose monthly dosing regimen as compared to the standard daily dosing regimen of risedronate 5 mg daily. Official Title A Phase III, Multicenter, Double-Blind, Randomized, Active-Controlled, Parallel Group, Non-Inferiority Study Comparing 150 mg Risedronate Monthly With 5 mg…
Bone
01 Jan 2013
Objectives Study in Rheumatoid Arthritis (The OSRA Study)
Rheumatoid synovitis causes largely irreversible damage to cartilage, bone and ligaments. Drug therapy aims to provide symptomatic relief but more importantly to suppress synovitis, or ‘disease activity’, in the hope that this will limit joint damage. Total elimination of disease is a challenging target in any patient and almost unachievable…
Bone
01 Jan 2013
A Study of the Safety and Efficacy of Intravenous CNTO 148 (Golimumab) in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy
The primary purpose of this study is to assess the clinical effectiveness and safety of intravenous (IV- injection directly into the vein) golimumab infusions every 12 weeks in patients with active rheumatoid arthritis (RA) despite current MTX treatment. The secondary objectives of this study are to evaluate the effects on…
Bone
01 Jan 2013
PRECISION : Prospective Randomized Evaluation of Celecoxib Integrated Safety vs Ibuprofen Or Naproxen
To answer the question of overall benefit: risk of celecoxib when compared to two most commonly prescribe traditional (non-selective) nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of arthritis pain. For this purpose, patients with osteoarthritis or rheumatoid arthritis with or at risk of developing cardiovascular disease will be recruited. The…
Bone
01 Jan 2013
Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis
The purpose of this study is to compare the efficacy of etanercept and sulphasalazine in the treatment of Ankylosing Spondylitis. Official Title A Randomized, Double-Blind Study Evaluating the Safety and Efficacy of Etanercept and Sulphasalazine in Subjects With Ankylosing Spondylitis Conditions Ankylosing Spondylitis Study Type Interventional Study Design Treatment,…
