Lungs
01 Jan 2013
Childhood Asthma Research and Education (CARE) Network
To evaluate current and novel therapies and management strategies for children with asthma. The emphasis is on clinical trials that help identify optimal therapy for children with different asthma phenotypes, genotypes, and ethnic backgrounds and children at different developmental stages. Official Title Conditions – Asthma- Lung Diseases Study Type…
Lungs
01 Jan 2013
Pollutant altered allergic response
This study is designed to investigate whether exposure to particulate air pollution increases the allergic response to allergens. Research studies suggest that symptoms in individuals with allergies may be aggravated by exposure to particulate air pollution. We sought to experimental determine this by exposing human volunteers to combustion particles, a…
Lungs
01 Jan 2013
A safety and efficacy trial evaluating the use of SanOrg34006 in the treatment of pulmonary embolism
Patients who have a pulmonary embolism (blood clot in the lung) will be treated in this study. The purpose of the study is to compare the safety and effectiveness of a new injectable anticoagulant (blood-thinning) drug, SanOrg34006, with the standard way of treating a pulmonary embolism. The standard treatment includes…
Infections
01 Jan 2013
Efficacy and Safety of Nasonex vs. Placebo in Subjects with SAR and Concomitant Asthma
An association between seasonal allergic rhinitis (SAR) and allergic asthma has been established through epidemiologic, pathophysiologic, and therapeutic studies. This study will compare Nasonex Nasal Spray to Placebo in treating the nasal and asthma symptoms experienced by subjects with SAR and concomitant asthma. Official Title Conditions – Rhinitis, Allergic, Seasonal-…
Heart
01 Jan 2013
Study of Heart Transplant Rejection
This study will investigate the causes of acute and chronic rejection of transplanted hearts. To find better ways to detect, treat and possibly prevent heart transplant rejection, more information about the cause is needed. Acute and chronic heart transplant rejection may be caused by certain substances the body produces in…
Heart
01 Jan 2013
Estrogen, Cytokines and Heart Failure in Women
To determine the effects of estrogen therapy on postmenopausal women with congestive heart failure. Official Title Conditions – Cardiovascular Diseases- Heart Failure, Congestive- Heart Diseases- Menopause Study Type Interventional Study Design Randomized, Double-Blind, Placebo Control Further Details BACKGROUND: Congestive heart failure (CHF) is a leading cause of morbidity,…
Lungs
01 Jan 2013
A study using an investigational new medicine looking at its effects on pulmonary function and respiratory symptoms in patients with chronic obstructive pulmonary disease (COPD)
Treatment with an investigational new medicine to determine if it improves lung function and decreases the symptoms of patients with chronic obstructive pulmonary disease (COPD) Official Title Conditions – Chronic Obstructive Pulmonary Disease Study Type Interventional Study Design Treatment Further Details Study Start Eligibility & Criteria Ages Eligible…
Heart
01 Jan 2013
Outcomes following myocardial revascularization: on and off cardiopulmonary bypass
Ischemic heart disease is one of the most frequent diagnoses in the VA system. Moreover, 5,819 coronary artery bypass graft (CABG-only) procedures were performed in the VA in FY 1999. Throughout VA and non-VA cardiac surgery programs nationwide, myocardial revascularization is now being performed using two surgical techniques. One technique…
Heart
01 Jan 2013
Efficacy and Cost Effectiveness of Relaxation and Response to CHF
Chronic heart failure (CHF) is a prevalent and costly disease. Because the incidence is higher among the elderly, the number of CHF patients is expected to rise as the population ages. Despite the development of significant pharmaceutical treatments, morbidity and mortality of CHF patients remain high, patients? quality of life…
