Mental Health
01 Jan 2013
MRI Study of Brain Activity and Risk for Depression in Adolescents
This study will use magnetic resonance imaging (MRI) to investigate brain changes in adolescents at risk for Major Depressive Disorder. It also calls for healthy volunteers to compare to children at risk for major depression. Official Title Neural Circuitry and Risk for Depression in Adolescents: A Study Using Functional Magnetic…
Mental Health
01 Jan 2013
Preventing the Recurrence of Depression with Drugs and Psychotherapy
The purpose of this study is to determine whether the addition of Cognitive Therapy (CT) to antidepressant medication (ADM) enhances treatment for depression. This study will also test whether the addition of CT to ADM will prevent recurrences of depression after therapy is over. Official Title Prevention of Recurrence in…
Mental Health
01 Jan 2013
Clonazepam and Paroxetine for Rapid Treatment of Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder (PTSD) is an anxiety disorder that follows exposure to an extremely traumatic stressors. PTSD is associated with serious symptoms. While numerous approaches have been used to treat PTSD, these treatments have several limiting factors. This study will evaluate a combination of the drugs clonazepam and paroxetine for…
Mental Health
01 Jan 2013
Effects of Arousal and Stress in Anxiety
This study has several parts. One part will examine the influence of factors such as personality and past experience on reactions to unpleasant stimuli. Others will examine the effect of personality and emotional and attentional states on learning and memory. Official Title Effects of Arousal and Stress on Classical Conditioning…
Mental Health
01 Jan 2013
Propranolol for the Treatment of Acute Stress Disorder
This 10-week study will examine whether propranolol, a medication that blocks the activity of the stress hormones adrenaline and noradrenaline, can relieve acute stress disorder (ASD) and symptoms from persisting long-term. ASD is a condition that some people develop soon after exposure to trauma. They may be anxious, depressed, have…
Mental Health
01 Jan 2013
Role of Dopamine in Response to Alcohol
This study will examine the role of the brain chemical dopamine in people’s response to alcohol consumption. Dopamine is thought to influence whether people have a strong or weak response to alcohol and how pleasurable that response is. The findings of this study may shed light on why some people…
Mental Health
01 Jan 2013
Serotonin Function During Depression
Serotonin is a chemical involved in regulation of emotions, anxiety, sleep, stress hormones, and other body functions. The purpose of this study is to use a procedure called tryptophan depletion to study the function of serotonin in people with depression and in healthy volunteers. Official Title Tryptophan Depletion and PET…
Mental Health
01 Jan 2013
Brain Imaging in Depression
The purpose of this study is to use brain imaging technology to examine the role of certain brain receptors and the nervous system chemical acetylcholine in major depression. Official Title Muscarinic Cholinergic Receptor Imaging in Depression Conditions – Depression- Bipolar Disorder Study Type Observational Study Design Natural History Further…
Mental Health
01 Jan 2013
Clinical Trial of Memantine for Major Depression
The purpose of this study is to determine the safety and effectiveness of the drug memantine for treating major depression. The purpose of this study is to determine the safety and effectiveness of the drug memantine for treating major depression.Major depression is a serious public health concern that contributes to…
