Infections
01 Jan 2013
Linezolid in the Treatment of Complicated Skin and Soft Tissue due to Methicillin-Resistant Staphylococcus Aureus
This is a Phase IV randomized, multi-center, open label trial to compare the clinical safety and efficacy of linezolid to vancomycin in the treatment of complicated skin and soft tissue infections due to methicillin-resistant staphylococcus aureus in adult subjects hospitalized for at least one day. Official Title Linezolid in the…
Cancer
01 Jan 2013
FASLODEX and AROMASIN in Hormone Receptor Positive Postmenopausal Women with Advanced Breast Cancer
The purpose of this study is to compare the efficacy of Faslodex (fulvestrant) to Aromasin (exemestane) in hormone receptor positive postmenopausal women with advanced breast cancer. Patients will be treated until disease progression or until the investigator has determined that treatment is not in the best interest of the patient,…
Gastro
01 Jan 2013
Medical and Surgical Treatment of Esophageal Reflux
The purpose of this project is to lay the groundwork for a proposed clinical trial to compare the effectiveness of two approaches to gastroesophageal reflux disease: treatment with medications and treatment with anti-reflux surgery. This project includes a non-interventional pilot study to test ways of measuring outcomes of treatment, and…
Bone
01 Jan 2013
Abatacept and Infliximab in Combination with Methotrexate in Subjects with Rheumatoid Arthritis
The purpose of this clinical research study is to learn if Abatacept in combination with Methotrexate and Infliximab demonstrate a greater reduction in disease activity over placebo. Official Title A Phase III, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Comparative Study of Abatacept or Infliximab in Combination with Methotrexate in Controlling Disease Activity…
Bone
01 Jan 2013
Effects of Arzoxifene on Bone Fractures and Incidence of Breast Cancer
The purpose of this trial is to study: – Effects of arzoxifene on bone fractures and bone mass. – Effects of arzoxifene on getting breast cancer. – Effects of arzoxifene on certain types of cardiovascular events, such as heart attack and stroke. – Effects of arzoxifene that…
Research and Trials
01 Jan 2013
A Randomized, Open-Label, Comparative Evaluation Of Conversion From Calcineurin Inhibitor Treatment To Sirolimus (Rapamune) Treatment versus Continued Calcineurin Inhibitor Treatment In Liver Allograft Recipients Undergoing Maintenance Therapy
To determine the effect of conversion from calcineurin inhibitor to sirolimus (Rapamune) treatment on kidney function. This study will also evaluate the safety and efficacy of the conversion of therapies. Official Title Conditions – Liver Transplantation- Hepatic Transplantation Study Type Interventional Study Design Treatment, Randomized, Open Label, Safety/Efficacy Study…
Hormones
01 Jan 2013
Reduction in the Occurrence of Center-Threatening Diabetic Macular Edema
The purpose of this study is to determine if ruboxistaurin can help slow the worsening of an eye disease called macular edema in patients with diabetes. Official Title Conditions Diabetic Retinopathy Study Type Interventional Study Design Treatment Further Details Study Start Eligibility & Criteria Inclusion Criteria:- You must have…
Infections
01 Jan 2013
Entecavir for Subjects with Chronic Hepatitis B Infection: An Early Access Program
The purpose of this clinical research study is to provide entecavir to subjects with chronic Hepatitis B infection who have failed or who have demonstrated intolerance of marketed therapies or for those in whom use of these agents is contraindicted and that have no other available treatment options. Official Title…
Cancer
01 Jan 2013
Combination Chemotherapy With or Without Rituximab in Treating Patients With Relapsed Non-Hodgkin’s Lymphoma
Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as rituximab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. It is not yet known whether chemotherapy is…
