The immune systems of some individuals may be capable of resisting HIV infection. These individuals do not appear to be infected with HIV despite multiple sexual encounters with HIV infected partners. This study will examine the immune systems of these individuals to determine what factors are responsible for their ability to resist HIV infection.
Official Title
Evaluation of HIV-Specific Immunological and Virological Responses of HIV-1 Multiply-exposed Seronegative Individuals
Conditions
HIV Infections
Study Type
Observational
Study Design
Natural History, Longitudinal, Defined Population, Prospective Study
Further Details
Rare individuals appear naturally resistant to overt HIV-1 infection despite repeated sexual exposures. These individuals, referred to as exposed seronegatives (ES), represent a unique population in which to evaluate mechanisms by which HIV-1 replication is either controlled or aborted. The purpose of the study is to analyze HIV-specific immune responses, both cellular and humoral, that exist in seronegative individuals who have experienced multiple exposures to HIV by sexual contact. This study will follow participants for 5 years. Participants will have 25 study visits during the study. Assessments will include HIV tests, viral load measurements, CD4 counts, pregnancy tests, and physical exams.
Study Start
Eligibility & Criteria
Ages Eligible for Study: 18 Years – 60 Years, Genders Eligible for Study: Both Accepts Healthy VolunteersCriteria Inclusion CriteriaNormal medical history and physical examination Unprotected sexual intercourse (anal and/or vaginal) with a known HIV infected person more than five times in the last 6 months or more than two times per week for a period of 4 months within the past 2 years HIV uninfected Acceptable methods of contraception Availability for follow-up for planned duration of study (minimum of 60 months) Exclusion CriteriaHistory of immunodeficiency, chronic illness, malignancy, autoimmune disease, or use of immunosuppressive medications History of cancer, unless there has been surgical excision followed by sufficient observation period to give a reasonable assurance of cure Medical or psychiatric condition or occupational responsibilities which could interfere with the study Active tuberculosis Prior HIV vaccine Pregnant or breastfeeding
Total Enrolment
100
Contact Details
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