Heart
01 Jan 2013
Estrogen, Cytokines and Heart Failure in Women
To determine the effects of estrogen therapy on postmenopausal women with congestive heart failure. Official Title Conditions – Cardiovascular Diseases- Heart Failure, Congestive- Heart Diseases- Menopause Study Type Interventional Study Design Randomized, Double-Blind, Placebo Control Further Details BACKGROUND: Congestive heart failure (CHF) is a leading cause of morbidity,…
Lungs
01 Jan 2013
A study using an investigational new medicine looking at its effects on pulmonary function and respiratory symptoms in patients with chronic obstructive pulmonary disease (COPD)
Treatment with an investigational new medicine to determine if it improves lung function and decreases the symptoms of patients with chronic obstructive pulmonary disease (COPD) Official Title Conditions – Chronic Obstructive Pulmonary Disease Study Type Interventional Study Design Treatment Further Details Study Start Eligibility & Criteria Ages Eligible…
Cancer
01 Jan 2013
Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug or combining radiation therapy with chemotherapy may kill more tumor cells. It is not yet known whether fluorouracil and mitomycin plus radiation therapy is more…
Gastro
01 Jan 2013
Phase 2 Evaluation of the ELAD System in the Management of Acute Liver Failure
The purpose of this study is to determine if treatment with the ELAD Bioartificial Liver Assist Device is beneficial to patients in Acute Liver Failure either as a bridge to liver transplant or bridge to native liver recovery. Official Title Conditions – Fulminant Hepatic Failure- Phase II Study Type Interventional…
Gastro
01 Jan 2013
Role of nitric oxide in cirrhosis: relationship with systemic hemodynamics, renal function, vasoactive systems and endotoxemia
This study is to determine whether a compound, nitric oxide, made within the body, is the factor responsible for the changes in blood pressure and renal (kidney) functions that may occur during the course of cirrhosis. Patients with cirrhosis (liver scarring which causes poor liver function) will be eligible to…
Gastro
01 Jan 2013
Treatment of Cholestatic Pruritus With Sertraline
The goal of this study is to find an effective and well-tolerated medical therapy for itching due to liver disease. Persons with primary biliary cirrhosis or chronic hepatitis C are currently being enrolled in the study. Persons participating in the study are given sertraline, a medication which is also often…
Gastro
01 Jan 2013
Evaluating Pancreatic Tumors in Patients with Zollinger-Ellison Syndrome
This protocol concerns the approach to the localization, diagnosis of MEN1 and management of the tumor and the tissue samples in patients with Zollinger-Ellison syndrome. It details the diagnostic imaging tests to be used to localize the tumor, investigations for MEN1 the subsequent management of the tumor and tissue samples…
Gastro
01 Jan 2013
The Use of Oral Omeprazole and Intravenous Pantoprazole in Patients with Hypersecretion of Gastric Acid
Patients with Zollinger-Ellison Syndrome suffer from ulcers of the upper gastrointestinal tract, higher than normal levels of gastric acid, and tumors of the pancreas known as non-beta islet cell tumors. Patients with Zollinger-Ellison Syndrome require continuous control of their gastric acid secretion. If gastric acid levels are permitted to rise…
Gastro
01 Jan 2013
Treatment of Zollinger-Ellison Syndrome
In patients with Zollinger-Ellison Syndrome the level of gastric acid is elevated. This increased level of gastric acid is what causes the symptoms of the disease. Certain types of medication can control the secretion of gastric acid. In this study there are details on how drugs known as antihistamines (H2…
