Mental Health
01 Jan 2013
Propranolol for the Treatment of Acute Stress Disorder
This 10-week study will examine whether propranolol, a medication that blocks the activity of the stress hormones adrenaline and noradrenaline, can relieve acute stress disorder (ASD) and symptoms from persisting long-term. ASD is a condition that some people develop soon after exposure to trauma. They may be anxious, depressed, have…
Chronic Pain
01 Jan 2013
Genetics of Fibromyalgia
The Fibromyalgia Family Study identifies and collects blood samples from families with two or more members affected with Fibromyalgia Syndrome (FMS). The primary goal of the study is to identify genes that predispose people to FMS and/or symptoms related to FMS; identifying these genes may lead to a better understanding…
Mental Health
01 Jan 2013
Serotonin in Alcoholism
This study uses positron emission tomography (PET) scanning to study how serotonin works in alcoholics. Serotonin is a chemical that allows brain cells to communicate. There is evidence that people with alcoholism have altered serotonin; their brains begin to make and break down serotonin more slowly than people who do…
Mental Health
01 Jan 2013
Role of Dopamine in Response to Alcohol
This study will examine the role of the brain chemical dopamine in people’s response to alcohol consumption. Dopamine is thought to influence whether people have a strong or weak response to alcohol and how pleasurable that response is. The findings of this study may shed light on why some people…
Gastro
01 Jan 2013
Genetic Linkage Study for Hereditary Pancreatitis
OBJECTIVES: Establish linkage in families with hereditary pancreatitis between the phenotype and a chromosomal locus (loci) that contains the responsible gene. Official Title – Pancreatitis Conditions Study Type Observational Study Design Natural History Further Details PROTOCOL OUTLINE: This is a genetics study. Blood samples are collected from patients…
Mental Health
01 Jan 2013
Serotonin Function During Depression
Serotonin is a chemical involved in regulation of emotions, anxiety, sleep, stress hormones, and other body functions. The purpose of this study is to use a procedure called tryptophan depletion to study the function of serotonin in people with depression and in healthy volunteers. Official Title Tryptophan Depletion and PET…
Mental Health
01 Jan 2013
Brain Imaging in Depression
The purpose of this study is to use brain imaging technology to examine the role of certain brain receptors and the nervous system chemical acetylcholine in major depression. Official Title Muscarinic Cholinergic Receptor Imaging in Depression Conditions – Depression- Bipolar Disorder Study Type Observational Study Design Natural History Further…
Mental Health
01 Jan 2013
Clinical Trial of Memantine for Major Depression
The purpose of this study is to determine the safety and effectiveness of the drug memantine for treating major depression. The purpose of this study is to determine the safety and effectiveness of the drug memantine for treating major depression.Major depression is a serious public health concern that contributes to…
Mental Health
01 Jan 2013
Clinical Trial of Tolcapone for Cognition in Schizophrenia
The purpose of this study is to test whether the drug tolcapone improves the memory of patients with schizophrenia. The purpose of this study is to test whether the drug tolcapone improves the memory of patients with schizophrenia.The catecholaminergic system can enhance some aspects of cognitive function, such as working…
