The Fibromyalgia Family Study identifies and collects blood samples from families with two or more members affected with Fibromyalgia Syndrome (FMS). The primary goal of the study is to identify genes that predispose people to FMS and/or symptoms related to FMS; identifying these genes may lead to a better understanding of the disease and more effective treatments.
Official Title
Fibromyalgia Family Study Registry
Conditions
– Fibromyalgia- Irritable Bowel Syndrome- Chronic Fatigue Syndrome- Depression
Study Type
Observational
Study Design
Natural History, Cross-Sectional, Convenience Sample, Retrospective Study
Further Details
FMS predominantly affects women and is characterized by chronic widespread musculoskeletal pain, fatigue, sleep disturbance, and multiple tender points on physical examination. The pathophysiological mechanisms underlying FMS are not clearly understood, but neuroendocrine factors seem to be of major importance. Studies of familial association suggest that genetic factors play a role in FMS. This study will establish patterns of genetic linkage in families with FMS. Participating family members will undergo a brief physical exam (including tender point exam), donate a blood sample, and complete a detailed questionnaire that includes experience with pain, fatigue, depression, bowel symptoms, headache, anxiety, and physical limitations. Measurements of serum serotonin and related compounds will also be obtained. To detect genetic factors, a genome-wide linkage scan using 405 microsatellite markers will be performed.
Study Start
Eligibility & Criteria
Ages Eligible for Study: 12 Years and above, Genders Eligible for Study: Both Criteria Inclusion CriteriaDiagnosed with fibromyalgia according to the criteria of the American College of Rheumatology Have at least one living family member who has also been diagnosed with fibromyalgia No other major rheumatological disease
Total Enrolment
560
Contact Details
[1] Jane M. Olson, PhD, Study Chair, Case Western Reserve UniversityAll content and media on the HealthEngine Blog is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. Always seek the guidance of your doctor or other qualified health professional with any questions you may have regarding your health or a medical condition. Never disregard the advice of a medical professional, or delay in seeking it because of something you have read on this Website. If you think you may have a medical emergency, call your doctor, go to the nearest hospital emergency department, or call the emergency services immediately.
Related Articles
Need a health appointment?
Find and book a doctor, dentist, physio and more on Healthengine
Find a practitioner
