Infections
01 Jan 2013
A Comparison of Two Ways to Manage Anti-HIV Treatment (The SMART Study)
The purpose of this study is to compare two ways of using anti-HIV drugs to help health care providers and patients decide how to best use anti-HIV treatments over many years. Many health care providers now treat patients with daily drugs to keep the viral load as low as possible.
Cancer
01 Jan 2013
Trial for First-Line Treatment of Colorectal Cancer
In this study, patients will receive either ALIMTA (pemetrexed) plus irinotecan or 5-fluorouracil (5-FU), leucovorin, and irinotecan. The purposes of this study are to determine: How ALIMTA plus irinotecan compares with 5-FU, leucovorin, and irinotecan in terms of efficacy. The safety of ALIMTA plus irinotecan and any side…
Gastro
01 Jan 2013
Nutritional Restriction and Activity Thermogenesis
These studies will provide us with enormous insight regarding how obese patients adapt energetically during negative energy balance. We will gain fundamental information regarding the metabolic implications of combining food restriction with a walking program compatible to that advocated by statutory agencies. These studies will lead to improved understanding of…
Bone
01 Jan 2013
Joint Injections for Osteoarthritic Knee Pain
The purpose of this study is to determine whether prolotherapy, a therapy based on injection of a sugar solution in and around the knee, can decrease pain and disability from knee osteoarthritis (OA). Official Title The Efficacy of Prolotherapy in Osteoarthritic Knee Pain Conditions -Treatment or Intervention Phase -Osteoarthritis-Procedure: Prolotherapy-Phase…
Bone
01 Jan 2013
Evaluation and Treatment of Skeletal Diseases
This study has four objectives: 1) to provide investigators the opportunity to study bone specimens from patients with various skeletal diseases; 2) to treat patients with skeletal diseases at the NIH; 3) to expose NIH trainees to certain skeletal diseases; and 4) to gain more knowledge about skeletal diseases and…
Bone
01 Jan 2013
Resistance to Vitamin D or Parathyroid Hormone
Patients with confirmed or suspected conditions with a resistance to vitamin D or parathyroid hormone (PTH) will be admitted for diagnosis and treatment, and inclusion in other studies pertaining to similar conditions. This study will provide information about problems relating to calcium in the blood, urine, and bones. Patients in…
Bone
01 Jan 2013
Lead Exposure, Genetics, and Osteoporosis Epidemiology
This study’s primary objective is to assess the effects of environmental lead exposures and genetic risk factors on the development of osteoporosis in middle-aged women. Official Title Conditions – Osteoporosis Study Type Observational Study Design Natural History, Longitudinal, Defined Population, Prospective Study Further Details Study Start Eligibility &…
Bone
01 Jan 2013
The Treatment and Natural History of Acromegaly
This study is directed toward acromegaly and treatment of patients with acromegaly. Acromegaly is a condition due to high levels of growth hormone in the blood. Growth hormone is responsible for the regulation of the metabolism of sugar, fat, and protein. When growth hormone levels are elevated patients may experience…
Bone
01 Jan 2013
Evaluation and Intervention for the Effects of Osteogenesis Imperfecta
We propose a longitudinal study of the natural history of types III and IV osteogenesis imperfecta for children age birth to 18 years. A consistent objective throughout this tudy is to obtain a comprehensive assessment of the natural history and progression of the multiple secondary features of osteogenesis imperfecta. In…
