Neurology
01 Jan 2013
Biological Markers in Parkinson’s Disease
This study will identify abnormalities of a protein called alpha synuclein that is found in the brain of patients with Parkinson’s disease and related disorders to see if it can serve as a disease marker. There is currently no treatment that will cure or delay progression of Parkinson’s disease. Thus,…
Mental Health
01 Jan 2013
Duloxetine Compassionate Use in Patients Who Have Completed a Previous Neuroscience Duloxetine Clinical Trial
The primary objective of this study is to provide duloxetine to investigators for the treatment of patients who have previously participated in neuroscience duloxetine clinical trials and for whom effective alternative therapy is not available. Official Title Open Label Duloxetine Compassionate Use in Patients Who Have Completed a Previous Neuroscience…
Heart
01 Jan 2013
PCI plus intensive medical therapy will be superior to intensive medical therapy alone in reducing all cause mortality or nonfatal MI
PCI (optimal catheter-based coronary revascularization) + intensive medical therapy is superior to intensive medical therapy alone using the combined endpoint of all-cause mortality or nonfatal MI. Official Title Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation Conditions – Myocardial Ischemia Study Type Interventional Study Design Randomized, Open Label, Uncontrolled, Single…
Mental Health
01 Jan 2013
Efficacy and Safety of Aricept in the Treatment of Severe Alzheimer’s Disease
Donepezil hydrochloride (Aricept) has been approved to treat symptoms associated with mild to moderate Alzheimer’s disease (AD). Aricept has been shown to improve the memory and thinking abilities, activities of daily living and global function in patients. The purpose of the study is to further investigate the effectiveness and safety…
Blood
01 Jan 2013
New Oral Anticoagulant Therapy for the Prevention of Blood Clots Following Hip or Knee Replacement Surgery
LY517717 (a capsule given by mouth) is a blood thinner that may prevent blood clots from forming in the legs and may prevent those blood clots from traveling to the lungs. Leg and lung blood clots occur commonly after patients have surgery to replace a hip or knee joint. These…
Lungs
01 Jan 2013
Evaluation of various doses of Ro 27-2771 (test drug) in asthmatic patients not treated with inhaled corticosteroids
The purpose of this study is to determine the appropriate dose of Ro 27-2441 (test drug) to be used in future studies, assess the efficacy and safety, and the anti-inflammatory action of the test drug in the treatment of asthmatic patients who are not currently receiving chronic therapy with corticosteroids.
Heart
01 Jan 2013
Irbesartan in Heart Failure with Preserved Systolic Function (I-Preserve)
The purpose of this clinical research study is to learn if Irbesartan is superior to placebo in reducing mortality and cardiovascular morbidity in subjects with heart failure with preserved systolic function. The safety of this treatment will also be studied. Official Title Conditions Congestive Heart Failure Study Type Interventional Study…
Children's health
01 Jan 2013
Safety and Efficacy Study of Etanercept (Enbrel) In Children with Systemic Onset Juvenile Rheumatoid Arthritis
This study will determine the efficacy of etanercept in children with systemically active systemic onset juvenile rheumatoid arthritis (SOJRA). Official Title Phase 3 Safety and Efficacy Study of Etanercept (Enbrel®) In Children with Systemic Onset Juvenile Rheumatoid Arthritis Conditions Arthritis, Juvenile Rheumatoid Study Type Interventional Study Design Treatment,…
Mental Health
01 Jan 2013
Clinical Trial of Pramipexole in Bipolar Depression
The purpose of this study is to examine the safety and effectiveness of the drug pramipexole given in combination with lithium or divalproex for the short-term treatment of acute depression in patients with bipolar disorder. Bipolar disorder is a severe, chronic, and often life-threatening illness. Treatments for acute unipolar…
