Irbesartan in Heart Failure with Preserved Systolic Function (I-Preserve)

The purpose of this clinical research study is to learn if Irbesartan is superior to placebo in reducing mortality and cardiovascular morbidity in subjects with heart failure with preserved systolic function. The safety of this treatment will also be studied.

Official Title

Conditions

Congestive Heart Failure

Study Type

Interventional

Study Design

Treatment

Further Details

Study Start

November 1, 2004

Eligibility & Criteria

Ages Eligible for Study: 60 Years and above, Genders Eligible for Study: Both Inclusion Criteria:- Male or female of Age >= 60 years with heart failure with preserved systolic function of the heart. – Left ventricular ejection fraction (LVEF) > = 45% – Willing to provide written informed consent AND Hospitalization for heart failure within the past 6 months OR Various abnormalities in electrocardiogram, echocardiogram or chest x-ray indicating heart disease. Exclusion Criteria:- Acute myocardial infarction within 3 months; – Heart revascularization procedure within 3 months; – Hospitalization for angina within 3 months; – Other heart surgery – Life-threatening or uncontrolled arrhythmia – Subjects with an implantable cardioverter-defibrillator that has discharged in the past 3 months; – Stroke or surgery of the arteries in the brain within 3 months; Serious lung disease which requires use of home oxygen. – Significantly low blood pressure – Significantly high blood pressure – Other known diseases that may limit life expectancy to <3 years; - Known or suspected bilateral kidney artery narrowing; - Geographic or social factors making study participation and follow-up impractical

Total Enrolment

Contact Details

BMS Call Center 1-866-892-1BMS Ext. 134 BMS Call Center Outside the US and Canada 1-215-247-4079 Ext. 134 Australia sites exist in all states please contact above for further details.