Cancer
01 Jan 2013
Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma
This randomized phase III trial is studying standard-dose radiation therapy to see how well it works compared to reduced-dose craniospinal radiation therapy AND posterior fossa boost radiation therapy to see how well it works compared to tumor bed boost radiation therapy when given together with chemotherapy in treating young patients…
Neurology
01 Jan 2013
Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone Therapy
The purpose of this trial is to determine if thymectomy combined with prednisone therapy is more beneficial in treating non-thymomatous myasthenia gravis than prednisone therapy alone. Official Title A Multi-Center, Single-Blind, Randomized Study Comparing Thymectomy to No Thymectomy in Non-Thymomatous Myasthenia Gravis (MG) Patients Receiving Prednisone Conditions Myasthenia Gravis…
Chronic Pain
01 Jan 2013
Oral Dexamethasone for Treatment of Migraine
The aim of this project is to determine if a single dose of oral dexamethasone at the time of discharge from the ED prevents rebound headache. Official Title Does a Single Oral Dose of Dexamethasone After Successful Emergency Treatment of Migraine Reduce the Incidence or Severity of Rebound Headache Within…
Neurology
01 Jan 2013
Evaluation of Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.
To determine long-term safety and efficacy of pregabalin in patients with partial seizures. Official Title Pregabalin Open-Label Add-On Trial: An Open-Label, Multicenter Follow-On Study to Determine Long-Term Safety and Efficacy in Patients With Partial Seizures. Conditions Seizure Disorder, Partial Study Type Interventional Study Design Treatment, Non-Randomized, Open Label,…
Neurology
01 Jan 2013
Efficacy and Safety of Fingolimod in Patients With Relapsing-Remitting Multiple Sclerosis With Optional Extension Phase (TRANSFORMS)
This study will assess safety, tolerability and efficacy of two doses of oral fingolimod versus interferon Beta-1a to reduce the frequency of relapses in patients with relapsing-remitting multiple sclerosis. Official Title A 12-Month Study Comparing the Efficacy and Safety of Two Doses of Fingolimod Versus Interferon Beta-1a in Patients With…
Neurology
01 Jan 2013
Study to Compare the Effect of Treatment With Carbidopa/Levodopa/Entacapone on the Quality of Life of Patients With Parkinson’s Disease.
This study examines the effect of treatment of levodopa/entacapone on quality of life, as measured by the Parkinson’s Disease-Questionnaire 8 (PDQ-8), in Parkinson’s disease patients with no or minimal, non-disabling motor fluctuations. Official Title A randomized, double-blind, parallel-group, multi-national study to compare the effect on quality of life of levodopa/carbidopa/entacapone…
Neurology
01 Jan 2013
Cooperative Huntington’s Observational Research Trial
The purpose of this study is to collect prospective data from individuals who are part of a Huntington Disease (HD) family, in order to relate phenotypes between individuals and families with each other and genetic factors in order to learn more about HD, develop potential treatments for HD, and to…
Research and Trials
01 Jan 2013
A Study to Determine the Long-Term Efficacy and Safety of Ramelteon in Adults With Chronic Insomnia.
The study will involve an evaluation of the efficacy and safety of ramelteon (TAK-375) over a 6-month period in adults and elderly subjects with chronic insomnia. The test agent ramelteon will be used at 8 mg fixed dose and the study will be conducted in multiple sites. Official Title A…
Mental Health
01 Jan 2013
Genetics of Obsessive-Compulsive Disorder
The purpose of this study is to identify genes that affect susceptibility to obsessive-compulsive disorder (OCD). By identifying genes that increase or decrease the risk of OCD, researchers can better understand how the condition develops and ultimately improve treatment for people with OCD. Official Title Genetics of Obsessive-Compulsive Disorder: A…
