Research and Trials
01 Jan 2013
Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO) (GALILEO)
To determine the efficacy of vascular endothelial growth factor (VEGF) Trap-Eye injected into the eye on vision function in subjects with macular edema as a consequence of central retinal vein occlusion. Official Title A Randomized, Double-masked, Sham-controlled Phase 3 Study of the Efficacy, Safety and Tolerability of Repeated Intravitreal Administration…
Research and Trials
01 Jan 2013
Dose Ranging Efficacy And Safety With Mepolizumab in Severe Asthma (DREAM)
The purpose of this study is to show whether mepolizumab given every 4 weeks intravenously (i.v.) can reduce the frequency of asthma exacerbations in subjects with severe asthma despite receiving high doses of standard asthma medications. The study will look at different doses of mepolizumab in comparison to a placebo.
Research and Trials
01 Jan 2013
CoreValve® System Australia/New Zealand Clinical Study
To evaluate the performance, efficacy and safety of the percutaneous implantation of the CoreValve® prosthetic aortic valve in patients with severe symptomatic native aortic valve stenosis that have an elevated surgical risk Official Title CoreValve® System Australia/New Zealand Clinical Study Conditions Aortic Valve Stenosis…
Research and Trials
01 Jan 2013
To Document the Effectiveness of BoNT-A Injection in Adult Subjects With Upper Limb Spasticity Following Stroke (ULIS2)
The purpose of the study is to assess the responder rate as defined by the achievement of the primary goal from the Goal Attainment Scale following one BoNT-A injection cycle in accordance with routine practices. Official Title An International, Prospective Cohort to Document the Effectiveness of One BoNT-A Injection Cycle…
Children's health
01 Jan 2013
Appropriate Oxygen Levels for Extremely Preterm Infants: a Prospective Meta-analysis (NeOProM)
For over 60 years the most appropriate oxygen level for preterm babies remains unknown. To answer this, we will combine data from over 5300 babies to be sure the expected benefits of lower oxygen for babies’ eyes and lungs does not come at the expense of increasing death or major…
Research and Trials
01 Jan 2013
A Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Prucalopride (Resolor) Tablets in Subjects With Chronic Constipation
The purpose of this study is to compare the efficacy and safety of prucalopride 2 mg given orally once daily for 12 weeks to those of placebo in treatment of chronic constipation. Prucalopride is an investigational drug that is being tested to see if it may be useful in treating…
Research and Trials
01 Jan 2013
A Study in Painful Diabetic Neuropathy (COMBO-DN)
This study will investigate the efficacy of a combination treatment of duloxetine + pregabalin compared with the maximal dose of each drug in monotherapy, in patients with diabetic peripheral neuropathic pain (DPNP) who have not responded to the standard recommended dose of either drug. It will provide an answer to…
Eye Care
01 Jan 2013
Cortical Markers for Glaucoma Research Project
Volunteers are needed for a research study into the effects of glaucoma on the brain. They will require two appointments in total. One of these will be at the Royal Victorian Eye and Ear Hospital, East Melbourne, where they will have a full eye examination and some imaging of…
Chronic Pain
01 Jan 2013
Migraine and Healthy Eyes Research Project
Volunteers are invited to participate in a research study assessing the effects of migraine headaches on visual function (HREC#0932638). The study will involve up to three test sessions, each of which may take up to three hours. During the sessions, the following will be performed:An eye examination to determine whether you are eligible to…
