Cancer
01 Jan 2013
FOLFOX4 in Patients with Normal and Abnormal Renal Function
This trial is a phase II study of patients with advanced gastrointestinal (GI) malignancies who will be assigned to one of 4 cohorts (normal, mild dysfunction, moderate dysfunction and severe renal dysfunction) based on their baseline measured creatinine clearance then treated with FOLFOX4. Standard bone marrow and liver function…
Gastro
01 Jan 2013
Medical and Surgical Treatment of Esophageal Reflux
The purpose of this project is to lay the groundwork for a proposed clinical trial to compare the effectiveness of two approaches to gastroesophageal reflux disease: treatment with medications and treatment with anti-reflux surgery. This project includes a non-interventional pilot study to test ways of measuring outcomes of treatment, and…
Cancer
01 Jan 2013
Vaccine Therapy in Treating Patients With Cancer of the Gastrointestinal Tract
Vaccines may make the body build an immune response to kill tumor cells. Vaccines may make the body build an immune response to kill tumor cells.Randomizedphase II trial to compare the effectiveness of two different vaccines in treating patients who have cancer of the gastrointestinal tract. Condition:- Gastrointestinal CancerStudy Type:…
Gastro
01 Jan 2013
Nutritional Restriction and Activity Thermogenesis
These studies will provide us with enormous insight regarding how obese patients adapt energetically during negative energy balance. We will gain fundamental information regarding the metabolic implications of combining food restriction with a walking program compatible to that advocated by statutory agencies. These studies will lead to improved understanding of…
Gastro
01 Jan 2013
Peptic Ulcer Hemorrhage Study
To evaluate the efficacy and safety of intravenous pantoprazole in the prevention of rebleeding in patients with bleeding peptic ulcer disease after successful endoscopic hemostatic therapy. Official Title An efficacy and safety study of intravenous pantoprazole in the prevention of recurrent peptic ulcer bleeding after successful hemostasis. Conditions – Peptic…
Gastro
01 Jan 2013
Barrett’s Esophagus Early Detection Study
The incidence rate for esophageal adenocarcinoma (EAC) has risen 10% per year over the past two decades and is the most rapidly increasing cancer in the U.S. Potential reasons for this increase include obesity and gastroesophageal reflux disease (GERD). Prevention strategies to date have focused on early detection. Barrett’s esophagus…
Gastro
01 Jan 2013
Peg-Intron for Prevention of Disease Progression in Chronic Hepatitis C Patients with Cirrhosis (failing with Interferon plus Ribavirin treatment)
The objective of the study is to evaluate the safety and efficacy of PEG-Intron vs. no treatment for the prevention of disease progression in adult subjects with compensated cirrhosis secondary to chronic hepatitis C, who failed to respond to therapy with an a interferon plus ribavirin. Official Title Peg-Intron for…
Gastro
01 Jan 2013
Computer Intervention for Prevention of Weight Regain
Many overweight patients are able to lose weight successfully, but then regain their weight. The purpose of this study is to develop and test the efficacy of 2 interventions to prevent weight regain in individuals who have recently lost weight. The two interventions being tested are a face-to-face group maintenance…
Gastro
01 Jan 2013
Genetic Linkage Study for Hereditary Pancreatitis
OBJECTIVES: Establish linkage in families with hereditary pancreatitis between the phenotype and a chromosomal locus (loci) that contains the responsible gene. Official Title – Pancreatitis Conditions Study Type Observational Study Design Natural History Further Details PROTOCOL OUTLINE: This is a genetics study. Blood samples are collected from patients…
