Gastro
01 Jan 2013
Long-Term Pantoprazole Trial in Patients With Symptoms of Chronic Acid Peptic Complaints (BY1023/VMG-708)
Gastroesophageal reflux disease (GERD) is a medical condition affecting the stomach and oesophagus. GERD might occur when the lower oesophageal sphincter does not close properly and stomach contents leaks back (refluxes) into the oesophagus. GERD is one of the most common medical disorders, with estimates of up to 50% of…
Gastro
01 Jan 2013
Incisionless Treatment for Patients With Inadequate Weight Loss Following Roux-en-Y Gastric Bypass
It is estimated that up to 20% of patients who have Roux-en-Y Gastric Bypass (RYGB) surgery will not meet their weight loss goal, or may even regain some of the weight they initially lost. One possible explanation is that the opening between the stomach pouch and the intestine becomes stretched.
Chronic Pain
01 Jan 2013
Effect of Escitalopram vs Reboxetine on Gastro-Intestinal Sensitivity of Patients With Major Depressive Disorder
Patients with major depressive disorder (MDD) commonly have many gastrointestinal complaints. Gastrointestinal pain is classified into 2 categories: visceral and somatic pain. The main aim of this study is to compare somatic and visceral sensitivity between healthy people and pateints with MDD. These two sensitivities will be assessed by the…
Gastro
01 Jan 2013
Foreshortened Oesophagus and Its Surgical Therapy (GERDSurgery)
The existence, diagnosis and treatment of short oesophagus is one of the controversies of the past which has recently re-emerged. The missed diagnosis of short oesophagus and the consequent inadequacy of treatment is one of the major causes of failure of antireflux surgery. Official Title Frequency, Predictors, Intraoperative Assessment and…
Gastro
01 Jan 2013
The Rabeprazole and Esomeprazole Reflux Assessment Trial (TREAT)
The primary objective of this study is to compare, the number of patients with heartburn and regurgitation symptom resolution after treatment with either rabeprazole 20 mg, esomeprazole 20 mg or esomeprazole 40 mg. Official Title A Study to Compare the Number of Patients With Gastro-Oesophageal Reflux Disease (GORD) Achieving Heartburn…
Gastro
01 Jan 2013
A Study to Evaluate the Efficacy and Safety of CCX282-B in Subjects With Moderate to Severe Crohn’s Disease
The purpose of this study is to determine whether CCX282-B is effective in treating patients with moderate to severe Crohn’s Disease. Official Title A Multinational, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of CCX282-B in Subjects With Moderate to Severe Crohn’s Disease Conditions Crohn’s Disease…
Cancer
01 Jan 2013
A Single Arm Trial of Oxaliplatin and 5FU With Concurrent Radiation in Patients With Metastatic Rectal Cancer
This trial is a single-arm study for patients presenting with both local and metastatic adenocarcinoma of rectum. The aims of the trial are (1) to determine the tolerability rate, and (2) to determine toxicity rates, pelvic and distant response rates in patients with locally advanced rectal cancer in the presence…
Gastro
01 Jan 2013
The Prevalence and Significance of Gastro-Oesophageal Reflux in Cystic Fibrosis Before and After Lung Transplantation
This study will determine the prevalence, severity and significance of symptomatic and silent GOR in adults with CF before and after lung transplant using 24hr oesophageal pH monitoring, a valid symptom questionnaire, quality of life questionnaires and gastric emptying studies. This study will identify the extent of GOR in a…
Cancer
01 Jan 2013
Celecoxib to Prevent Colorectal Cancer in Patients Who Have Undergone Surgery to Remove Polyps
This randomized phase III trial is studying celecoxib to see how well it works compared to a placebo in preventing the development of adenomatous colorectal polyps in patients who have had at least one polyp removed. Official Title Prevention of Sporadic Colorectal Adenomas With Celecoxib (APC) Conditions Colorectal Cancer Study…
