Cancer
01 Jan 2013
Immunotherapy Using Cyclosporine, Interferon Gamma, and Interleukin-2 After High-Dose Myeloablative Chemotherapy With Autologous Stem Cell Transplantation in Treating Patients With Refractory or Relapsed Hodgkin’s Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with autologous stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. Giving immunotherapy using cyclosporine, interferon gamma, and…
Bone
01 Jan 2013
A Phase I/II Study of PBPC Mobilisation with VTP195183 Plus G-CSF Compared to Mobilisation with G-CSF Alone
Hematopoietic stem cells (HSC) are used to support the administration of high dose chemotherapy for a range of human cancers. For a safe HSC transplantation, a minimum of 5 million HSC per kilogram are required. HSC are collected from the bone marrow by using drugs such as G-CSF (filgrastim) which…
Cancer
01 Jan 2013
Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT)
The purpose of this study is to determine whether treatment with etoposide, doxorubicin, cisplatin and mitotane (EDP/M) prolongs survival as compared to streptozotocin and mitotane (Sz/M) in patients with advanced adrenocortical carcinoma (ACC) whose disease is not amenable to complete surgical resection. The Firm-ACT trial is the first ever conducted…
Cancer
01 Jan 2013
Combination Chemotherapy After Surgery in Treating Patients With Stage I, Stage II, or Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which combination chemotherapy regimen is more effective after surgery in treating breast cancer. PURPOSE: Randomized phase III trial to compare different combination chemotherapy regimens…
Cancer
01 Jan 2013
A Feasibility Study to Evaluate Adjuvant Chemoradiotherapy for Gastric Cancer
The purpose of this study is to determine the side-effects and effectiveness of a new type of chemoradiotherapy treatment for patients who have had surgery for stomach cancer. The treatment uses epirubicin, cisplatin, and 5-fluorouracil (ECF) chemotherapy together with radiotherapy. Official Title Conditions Gastric Cancer Study Type Interventional Study Design…
Cancer
01 Jan 2013
Outcomes of Concurrent Chemo-Radiotherapy in Locally Advanced Cervical Cancer.
CCRT is considered the standard of care in LACC since 1999. However there are few reports of results of this treatment in the common practice in developing countries were this disease is most frequent. Official Title Outcomes of Concurrent Chemo-Radiotherapy (CCRT) in Locally Advanced Cervical Cancer (LACC). Results of a…
Cancer
01 Jan 2013
Combination chemotherapy of docetaxel, ifosfamide and cisplatin (DIP) in patients with metastatic urothelial cancer
The aim of this study was to evaluate the efficacy and toxicity of a new combination chemotherapy of docetaxel, ifosfamide and cisplatin (DIP) in the treatment of metastatic urothelial cancer. Official Title Combination chemotherapy of docetaxel, ifosfamide and cisplatin (DIP) in patients with metastatic urothelial cancer: a preliminary report. Conditions…
Cancer
01 Jan 2013
Study of irinotecan (CPT-11) combined with fixed dose of 5-fluorouracil (5-FU) adult patients with advanced solid tumours
Advanced solid tumors (gastrointestinal incl. Colorectal, head & neck, others) (1): to find the maximum tolerated dose (MTD) of the combined chemotherapy. (2): to determine the quantitive and qualitative toxic effects, the Dose-limiting toxicity and the recommended dose for phase II trials. (3): to define the safety profile…
Cancer
01 Jan 2013
Irinotecan (CPT-11)-based chemotherapy as induction treatment for advanced colorectal cancer
Advanced colorectal cancer (ACRC) To determine complete resection (R0), response rate, time to progression (TTP) and overall survival (OS) in patients with non-resectable ACRC after being treated with neoadjuvant irinotecan-based chemotherapy. Official Title Conditions Study Type Retrospective analysis Study Design Further Details Treatment Details:Irinotecan 250 mg/m2 i.v. (1h)…
