Cancer
01 Jan 2013
Androgen Deprivation Therapy in Treating Patients With Prostate Cancer
Rationale: Androgens can cause the growth of prostate cancer cells. Androgen deprivation therapy may stop the adrenal glands from making androgens. Purpose: This randomized phase III trial is studying how well androgen deprivation therapy works in treating patients with prostate cancer. Official Title Phase III Randomized Study of Delayed…
Cancer
01 Jan 2013
Two Chemotherapy Regimens Compared With Observation in Treating Patients With Completely Resected Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which chemotherapy regimen is more effective, or whether chemotherapy is more effective than observation, in treating pancreatic cancer after surgery. PURPOSE: Phase III trial…
Cancer
01 Jan 2013
Chemoradiotherapy in Patients with Localised Lung Cancer
The study compares 2 different methods of combined chemotherapy and radiotherapy for the treatment of localised lung cancer in patients not suitable for surgery. Hypothesis(es) to be tested: 1) Vinorelbine + cisplatin + high-dose palliative radiotherapy is superior to gemcitabine + high dose palliative radiotherapy in terms of efficacy…
Cancer
01 Jan 2013
The IVADo regimen for children with metastatic soft tissue sarcoma
Objectives: To evaluate the feasibility of an intensified induction regimen (IVADo), which combines doxorubicin, with the well established ifosfamide, vincristine and actinomycin D (IVA) regimen. Conclusions from the authors: The intensive IVADo regimen was effective against pediatric STS with acceptable toxicity. This combination will be investigated in high-risk…
Cancer
01 Jan 2013
IEV and autologous peripheral blood progenitor cell transplant salvage treatment for lymphoid malignancies
Primary endpoints were to confirm the feasibility and efficacy of IEV in poor risk Hodgkin’s lymphoma and aggressive NHLs. Additional endpoints were to try to evaluate its possible role in the salvage strategy of indolent NHLs, lymphoblastic lymphoma and multiple myeloma. Analysis of toxicity and PBSC mobilization. Conclusions…
Cancer
01 Jan 2013
Head and Neck Phase III Iressa Vs Methotrexate Refractory. Iressa Vs Methotrexate (IMEX)
Purpose- This study is to compare ZD1839 (250mg and 500mg) versus methotrexate in head and neck cancer in terms of overall survival. Official Title A Phase III Randomised, Stratified, Parallel-Group, Mulit-Centre, Comparative Study of ZD1839 (Iressa) 250 mg and 500 mg Versus Methotraxate for Previously Treated Patients with Squamous Cell…
Cancer
01 Jan 2013
Eflornithine and Sulindac in Preventing Colorectal Cancer in Patients With Colon Polyps
Rationale: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of eflornithine and sulindac may prevent colorectal cancer. It is not yet known whether eflornithine and sulindac are more effective than a placebo in preventing colorectal cancer. Purpose: This randomized…
Cancer
01 Jan 2013
Tirapazamine, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer
RATIONALE: Drugs used in chemotherapy, such as tirapazamine and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Tirapazamine may help cisplatin kill more tumor cells by making tumor cells more sensitive to the drug. Radiation…
Cancer
01 Jan 2013
Brain Metastases Study
Purpose- Comparison of radiotherapy fractionation schemes for brain metastasis. Official Title To Determine Which of Two Radiotherapy Brain Fractionation Schemes is Superior in the Treatment of Brain Metastases Conditions Study Type Interventional Study Design Treatment, Randomized, Open Label, Dose Comparison, Parallel Assignment, Efficacy Study Further Details Primary Outcomes: Control of…
