The purpose of this study is to determine whether the daily inhalation of nebulised hypertonic saline (6%) will decrease the incidence of pulmonary exacerbations and increase the quality of life for people with non cystic fibrosis bronchiectasis.
Official Title
Conditions
Bronchiectasis
Study Type
Interventional
Study Design
Treatment, Randomized, Single Blind, Active Control, Parallel Assignment
Further Details
Primary Outcome Measures:
- Number of pulmonary exacerbations [Time Frame: One year]
Secondary Outcome Measures:
- St George Respiratory questionnaire
- Leicester Cough Questionnaire
- Lung Function Tests [Time Frame: One year]
The aim of this project is to determine the long term effect of the daily inhalation of hypertonic saline on respiratory infections, quality of life, lung function and hospital admissions in patients with non cystic fibrosis bronchiectasis. Hypertonic saline has been shown to be beneficial as a once only treatment in this patient group, but its’ long term effects have not been studied. Participants will be randomised to two groups – those receiving hypertonic saline (6%) and those receiving isotonic saline (0.9%) – and will be blinded to the treatment that they are receiving. They will be given nebuliser equipment and will be instructed how and when to inhale their medication. Objective measures will be taken by a blinded assessor before the commencement of the project and then at 3 months and 6 months post commencement.
Study Start
August 2007; Expected completion: August 2008
Eligibility & Criteria
- Ages Eligible for Study: 18 Years and above
- Genders Eligible for Study: Both
Inclusion Criteria:
- diagnosis of bronchiectasis
- at least 2 respiratory exacerbations per year over the past 2 years
- producing sputum daily
- in a stable clinical state
- over 18 years of age.
Exclusion Criteria:
- cystic fibrosis or allergic broncho-pulmonary aspergillosis phenotypes.
Total Enrolment
32
Contact Details
The Alfred Hospital, Melbourne, Victoria, 3126, Australia
- Caroline H Nicolson, MPhysio: +613 9076 3450; c.nicolson@alfred.org.au
All content and media on the HealthEngine Blog is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. Always seek the guidance of your doctor or other qualified health professional with any questions you may have regarding your health or a medical condition. Never disregard the advice of a medical professional, or delay in seeking it because of something you have read on this Website. If you think you may have a medical emergency, call your doctor, go to the nearest hospital emergency department, or call the emergency services immediately.
Related Articles
Need a health appointment?
Find and book a doctor, dentist, physio and more on Healthengine
Find a practitioner
