Research and Trials
01 Jan 2013
A Randomized, Open-Label, Comparative Evaluation Of Conversion From Calcineurin Inhibitor Treatment To Sirolimus (Rapamune) Treatment versus Continued Calcineurin Inhibitor Treatment In Liver Allograft Recipients Undergoing Maintenance Therapy
To determine the effect of conversion from calcineurin inhibitor to sirolimus (Rapamune) treatment on kidney function. This study will also evaluate the safety and efficacy of the conversion of therapies. Official Title Conditions – Liver Transplantation- Hepatic Transplantation Study Type Interventional Study Design Treatment, Randomized, Open Label, Safety/Efficacy Study…
Heart
01 Jan 2013
Registry of Fabry Disease – A Multicenter Observational Study
The purpose of this study is to compile a registry of patients with Fabry disease, an inherited metabolic disorder. In this disease, an enzyme called a-galactosidase A, which normally breaks down a lipid (fatty substance) called globotriaosylceramide (Gb3), is missing or does not function properly. As a result, Gb3 accumulates,…
Cancer
01 Jan 2013
Bortezomib in Treating Patients With Advanced Cancer and Kidney Dysfunction
RATIONALE: Bortezomib may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth. RATIONALE: Bortezomib may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth.PURPOSE: Phase I trial to study the effectiveness of bortezomib in treating patients who have…
Research and Trials
01 Jan 2013
Renal Allograft Recipients Study
To determine the effect of conversion from calcineurin inhibitor to sirolimus based therapy on renal function. Official Title A randomized, open-label, comparative evaluation of conversion from calcineurin inhibitors to sirolimus versus continued use of calcineurin inhibitors in renal allograft recipients. Conditions – Renal Allograft Recipients Study Type Interventional Study…
Research and Trials
01 Jan 2013
The safe use of RO0503821 for the maintenance treatment of anemia in patients w/ chronic kidney disease who are on dialysis
The primary purpose of this study is to demonstrate that RO0503821 administered intravenously maintains hemoglobin concentrations in dialysis patients on prior intravenous darbepoetin alfa maintenance treatment of chronic renal anemia. The secondary purpose is to assess the safety and tolerability of intravenous administration of RO0503821 in this patient population. Official…
Research and Trials
01 Jan 2013
Clinical Trial to Slow the Progression of ADPKD
This study will determine whether certain blood pressure medications will slow cyst growth or keep kidneys functioning longer in patients with autosomal dominant polycystic kidney disease (ADPKD). The study will take place at several sites in the United States. The start date of the study has not yet been determined.
Research and Trials
01 Jan 2013
Study to Evaluate the Effects of Zemplar Injection and Calcijex on Intestinal Absorption of Calcium
A study to investigate the effects of Zemplar and Calcijex on intestinal calcium absorption in hemodialysis subjects Condition: – Hypoparathyroidism – Hypercalcemia – Kidney Failure, Chronic Official Title A Phase IV, Single-Center, Active-Controlled Cross-Over Pilot Study to Evaluate the Effects of Zemplar Injection and Calcijex on Intestinal…
Cancer
01 Jan 2013
“REDUCE” – A Clinical Research Study To Reduce The Incidence Of Prostate Cancer In Men Who Are At Increased Risk
Purpose This 4-year study will compare how safe and effective an oral investigational medicine is (compared to placebo) in preventing the development of prostate cancer in men that are defined by the study entrance criteria as being at an increased risk for prostate cancer. Study visits to the clinic…
Bone
01 Jan 2013
Look AHEAD
Purpose The Look AHEAD study is a multicenter, randomized clinical trial to examine the long-term effects of a lifestyle intervention designed to achieve and maintain weight loss. The study will investigate the effects of the intervention on heart attacks, stroke and cardiovascular-related death in individuals with type 2 diabetes…
