Heart
01 Jan 2013
PCI plus intensive medical therapy will be superior to intensive medical therapy alone in reducing all cause mortality or nonfatal MI
PCI (optimal catheter-based coronary revascularization) + intensive medical therapy is superior to intensive medical therapy alone using the combined endpoint of all-cause mortality or nonfatal MI. Official Title Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation Conditions – Myocardial Ischemia Study Type Interventional Study Design Randomized, Open Label, Uncontrolled, Single…
Mental Health
01 Jan 2013
Efficacy and Safety of Aricept in the Treatment of Severe Alzheimer’s Disease
Donepezil hydrochloride (Aricept) has been approved to treat symptoms associated with mild to moderate Alzheimer’s disease (AD). Aricept has been shown to improve the memory and thinking abilities, activities of daily living and global function in patients. The purpose of the study is to further investigate the effectiveness and safety…
Blood
01 Jan 2013
New Oral Anticoagulant Therapy for the Prevention of Blood Clots Following Hip or Knee Replacement Surgery
LY517717 (a capsule given by mouth) is a blood thinner that may prevent blood clots from forming in the legs and may prevent those blood clots from traveling to the lungs. Leg and lung blood clots occur commonly after patients have surgery to replace a hip or knee joint. These…
Lungs
01 Jan 2013
Evaluation of various doses of Ro 27-2771 (test drug) in asthmatic patients not treated with inhaled corticosteroids
The purpose of this study is to determine the appropriate dose of Ro 27-2441 (test drug) to be used in future studies, assess the efficacy and safety, and the anti-inflammatory action of the test drug in the treatment of asthmatic patients who are not currently receiving chronic therapy with corticosteroids.
Cancer
01 Jan 2013
Pain Control in Patients With Recurrent or Metastatic Breast or Prostate Cancer
RATIONALE: An outpatient educational and behavioral skills training program may help patients with metastatic breast or prostate cancer live longer and more comfortably. PURPOSE: Randomizedpilot study to evaluate whether an outpatient educational and behavioral skills training program will improve pain control in patients who have metastatic or recurrent breast…
Heart
01 Jan 2013
Fondaparinux Use in a Broad Range of Patients with ST-segment Elevation Acute Myocardial Infarction (MI)
The purpose of this research study is to determine the efficacy and safety of fondaparinux (Arixtra) in preventing death and repeat heart attacks and their complications. Official Title Safety and efficacy trial evaluating fondaparinux use in a broad range of patients with ST segment elevation acute MI Conditions – Myocardial…
Lungs
01 Jan 2013
APPLES: Apnea Positive Pressure Long-Term Efficacy Study
To determine the effectiveness of nasal continuous positive airway pressure (CPAP) therapy for the treatment of obstructive sleep apnea syndrome. Official Title – Lung Diseases- Sleep Apnea Syndromes- Sleep Conditions Study Type Interventional Study Design Treatment, Randomized Further Details BACKGROUND: Nasal continuous positive airway pressure (CPAP) therapy is in widespread…
Cancer
01 Jan 2013
A Dose-Escalation Vaccine Trial In HER2-Overexpressing Patients With High-Risk Breast Cancer
This trial will test how safe this vaccine is. It also tests whether its introduction induces an immune response by stimulating the patient’s own immune system to recognize a specific target molecule called HER2, which is overexpressed in many breast cancers. This trial will test how safe this vaccine is.
Heart
01 Jan 2013
A safety and efficacy trial evaluating the use of SanOrg34006 compared to warfarin or acenocoumarol in patients with atrial fibrillation
This trial will include patients who have a heart condition called atrial fibrillation. Atrial fibrillation is an abnormal rhythm (irregular beat) in the heart. Patients with atrial fibrillation have an increased chance for a blood clot to form in the heart and move to other blood vessels in the body…
