Cardiology

Heart 01 Jan 2013

Can a Modified Fat Diet With Low Glycaemic Load Improve Insulin Sensitivity and Inflammatory Mediators in Overweight People With Chronic Heart Failure?

In overweight patients with chronic heart failure, to compare the effects of a modified fat diet with reduced glycaemic load (diet 1), and a conventional low fat, high carbohydrate diet (diet 2) on: insulin sensitivity (using the HOMA model); lipid profile; symptomatic status ( 6 minute walk distance and heart…
Heart 01 Jan 2013

‘CardioFit’ for the Treatment of Heart Failure

In this study, the safety and efficacy of a new vagus nerve stimulating system will be evaluated. This study will compare whether the new device improves Heart Failure parameters in Class II – III Heart Failure patients. Pharmacologic antagonism of the beta-adrenergic receptors shifting the autonomic balance in the…
Heart 01 Jan 2013

FREEDOM-C: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor for the Treatment of Pulmonary Arterial Hypertension (PAH)

This study is an international, multi-center, randomized, double-blind, placebo-controlled study in subjects with PAH who are currently receiving approved therapy for their PAH (i.e. endothelin receptor antagonist and/or phosphodiesterase-5 inhibitor). Study visits will occur at 4 week intervals for 16 weeks with the key measure of efficacy being the 6-minute…
Heart 01 Jan 2013

Optimal Loading Dose of SR25990C in Patients Planned for Percutaneous Coronary Intervention

The purpose of this study is to evaluate whether a higher dosage of clopidogrel with aspirin (two doses) will decrease the risk of ischemic complications (cardiac death, stroke, myocardial infarction) after a percutaneous coronary intervention. Official Title CURRENT/OASIS 7: Clopidogrel Optimal Loading Dose Usage to Reduce Recurrent EveNTs/Optimal Antiplatelet Strategy…
Follow-Up Serial Infusions of Natrecor(R) (Nesiritide) for the Management of Patients with Heart Failure-FUSION II
Heart 01 Jan 2013

Follow-Up Serial Infusions of Natrecor(R) (Nesiritide) for the Management of Patients with Heart Failure-FUSION II

The purpose of this study is to evaluate the efficacy and safety of Natrecor(R) administered as serial infusions to heart failure (HF) patients in the outpatient setting. Official Title Conditions Heart Failure, Congestive Study Type Interventional Study Design Treatment, Randomized, Double-Blind, Placebo Control, Single Group Assignment, Safety/Efficacy Study Further…
A Comparison of CS-747 and Clopidogrel in Acute Coronary Syndrome Subjects Who Are to Undergo Percutaneous Coronary Intervention
Heart 01 Jan 2013

A Comparison of CS-747 and Clopidogrel in Acute Coronary Syndrome Subjects Who Are to Undergo Percutaneous Coronary Intervention

The sponsors of this investigational drug are developing prasugrel as a possible treatment for patients with acute coronary syndrome (heart attack or chest pain) who need, or are expected to need, a percutaneous coronary intervention (PCI; also called a balloon angioplasty). Prasugrel will be compared with clopidogrel to determine which…
Heart 01 Jan 2013

Efficacy and Safety of Oral Bosentan in Pulmonary Arterial Hypertension Class II

The present trial investigates a possible use of oral bosentan, which is currently approved for the treatment of symptoms of pulmonary arterial hypertension (PAH) Class III and IV, to patients suffering from PAH Class II. Official Title A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess the Efficacy, Safety, and Tolerability…
Levosimendan versus Dobutamine in Shock Patients
Blood 01 Jan 2013

Levosimendan versus Dobutamine in Shock Patients

The purpose of the study is to compare the efficacy of levosimendan with that of dobutamine in patients with unstable hemodynamics (shock). Official Title Efficacy of Levosimendan in the Critically Ill Patients with Unstable Hemodynamics (the LICI study) – A Double Blind Randomized Pilot Study Conditions – Cardiogenic Shock-…
Safety of NXY-059 for the Treatment of Patients who have Suffered from a Stroke
Blood 01 Jan 2013

Safety of NXY-059 for the Treatment of Patients who have Suffered from a Stroke

This study will determine if NXY-059 is safe in patients with an acute stroke caused by bleeding in the central nervous system. Official Title CHANT (Cerebral Hemorrhage And NXY Treatment) A Double-Blind, Randomized, Placebo-Controlled, Parallel group, Multicenter, Phase IIb Study to Assess the Safety and Tolerability of Intravenous Infusion of…