Heart
01 Jan 2013
Can a Modified Fat Diet With Low Glycaemic Load Improve Insulin Sensitivity and Inflammatory Mediators in Overweight People With Chronic Heart Failure?
In overweight patients with chronic heart failure, to compare the effects of a modified fat diet with reduced glycaemic load (diet 1), and a conventional low fat, high carbohydrate diet (diet 2) on: insulin sensitivity (using the HOMA model); lipid profile; symptomatic status ( 6 minute walk distance and heart…
Heart
01 Jan 2013
‘CardioFit’ for the Treatment of Heart Failure
In this study, the safety and efficacy of a new vagus nerve stimulating system will be evaluated. This study will compare whether the new device improves Heart Failure parameters in Class II – III Heart Failure patients. Pharmacologic antagonism of the beta-adrenergic receptors shifting the autonomic balance in the…
Heart
01 Jan 2013
FREEDOM-C: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor for the Treatment of Pulmonary Arterial Hypertension (PAH)
This study is an international, multi-center, randomized, double-blind, placebo-controlled study in subjects with PAH who are currently receiving approved therapy for their PAH (i.e. endothelin receptor antagonist and/or phosphodiesterase-5 inhibitor). Study visits will occur at 4 week intervals for 16 weeks with the key measure of efficacy being the 6-minute…
Heart
01 Jan 2013
Optimal Loading Dose of SR25990C in Patients Planned for Percutaneous Coronary Intervention
The purpose of this study is to evaluate whether a higher dosage of clopidogrel with aspirin (two doses) will decrease the risk of ischemic complications (cardiac death, stroke, myocardial infarction) after a percutaneous coronary intervention. Official Title CURRENT/OASIS 7: Clopidogrel Optimal Loading Dose Usage to Reduce Recurrent EveNTs/Optimal Antiplatelet Strategy…
Heart
01 Jan 2013
Follow-Up Serial Infusions of Natrecor(R) (Nesiritide) for the Management of Patients with Heart Failure-FUSION II
The purpose of this study is to evaluate the efficacy and safety of Natrecor(R) administered as serial infusions to heart failure (HF) patients in the outpatient setting. Official Title Conditions Heart Failure, Congestive Study Type Interventional Study Design Treatment, Randomized, Double-Blind, Placebo Control, Single Group Assignment, Safety/Efficacy Study Further…
Heart
01 Jan 2013
A Comparison of CS-747 and Clopidogrel in Acute Coronary Syndrome Subjects Who Are to Undergo Percutaneous Coronary Intervention
The sponsors of this investigational drug are developing prasugrel as a possible treatment for patients with acute coronary syndrome (heart attack or chest pain) who need, or are expected to need, a percutaneous coronary intervention (PCI; also called a balloon angioplasty). Prasugrel will be compared with clopidogrel to determine which…
Heart
01 Jan 2013
Efficacy and Safety of Oral Bosentan in Pulmonary Arterial Hypertension Class II
The present trial investigates a possible use of oral bosentan, which is currently approved for the treatment of symptoms of pulmonary arterial hypertension (PAH) Class III and IV, to patients suffering from PAH Class II. Official Title A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess the Efficacy, Safety, and Tolerability…
Blood
01 Jan 2013
Levosimendan versus Dobutamine in Shock Patients
The purpose of the study is to compare the efficacy of levosimendan with that of dobutamine in patients with unstable hemodynamics (shock). Official Title Efficacy of Levosimendan in the Critically Ill Patients with Unstable Hemodynamics (the LICI study) – A Double Blind Randomized Pilot Study Conditions – Cardiogenic Shock-…
Blood
01 Jan 2013
Safety of NXY-059 for the Treatment of Patients who have Suffered from a Stroke
This study will determine if NXY-059 is safe in patients with an acute stroke caused by bleeding in the central nervous system. Official Title CHANT (Cerebral Hemorrhage And NXY Treatment) A Double-Blind, Randomized, Placebo-Controlled, Parallel group, Multicenter, Phase IIb Study to Assess the Safety and Tolerability of Intravenous Infusion of…
