Heart
01 Jan 2013
A Trial of INO-1001 in Patients Undergoing Heart Surgery That Involves Heart-Lung Bypass
The purpose of this study is to assess the safety of INO-1001, an intravenous PARP (poly-polymerase) inhibitor, in patients undergoing heart surgery. The study also measures whether INO-1001 reduces the side effects caused by heart-lung bypass machines. Official Title A Phase II Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate Tolerability,…
Heart
01 Jan 2013
Secondary Prevention of Venous Thrombo Embolism.
The general aim of this study is to determine the comparative safety and efficacy of dabigatran etexilate administered orally and warfarin (INR of 2.0-3.0) for the long-term treatment and secondary prevention of symptomatic venous thromboembolism in patients who have been successfully treated with standard doses of an approved anticoagulant for…
Heart
01 Jan 2013
ThromboEmbolism Prevention Efficacy and Safety Trial (TEMPEST)
The purpose of this study is to gain additional safety information as well as to determine after the study drug has been given to patients who have undergone total hip replacement surgery, whether the study drug is effective in preventing late deep vein thrombosis (blood clots in legs) or pulmonary…
Heart
01 Jan 2013
A Comparison of AZD6140 and Clopidogrel in Patients With Acute Coronary Syndrome
AZD6140 is a new, reversible, anti-platelet medication. Anti-platelet medications work to prevent the formation of blood clots. AZD6140 is being developed as a treatment for patients with acute coronary syndrome (ACS). ACS is a term that is used to describe both heart attacks in progress or the imminent threat of…
Heart
01 Jan 2013
Alternative Risk Markers in Coronary Artery Disease (ARMCAD)
The aim of this study is to assess several known and a few novel risk-factors (heart rate variability, pulse wave analysis, high-sensitivity CRP and BNP) prior to planned elective coronary angiography. Official Title Correlation of Multiple Risk Factors With Presence and Severity of Coronary Artery Disease on Angiography. Conditions Coronary…
Heart
01 Jan 2013
A Study To Evaluate the Effect of Rosuvastatin On Intravascular Ultrasound-Derived Coronary Atheroma Burden (ASTEROID)
The purpose of this study is to see if 40 mg of rosuvastatin taken daily will reduce the atherosclerosis (fatty deposits) in your arteries Official Title A 104-Week, Open-Label, Multi-Centre, Phase IIIb Study Evaluating the Effect of Treatment With Rosuvastatin 40 Mg on Atherosclerotic Disease as Measured by Intravascular Ultrasound…
Heart
01 Jan 2013
Ancrod (Viprinex) for the Treatment of Acute, Ischemic Stroke
The primary purpose of this study is to determine whether a brief intravenous infusion of ancrod started within 6 hours of stroke onset improves functional outcome at 3 months. Official Title Study of Acute Viprinex for Emergency Stroke: A Randomized, Double-Blind, Placebo-Controlled Study of Ancrod (Viprinex) in Subjects Beginning Treatment…
Heart
01 Jan 2013
Lipitor In The Prevention Of Stroke, For Patients Who Have Had A Previous Stroke (SPARCL)
To determine whether Lipitor reduces stroke, compared to placebo in patients who have had a previous stroke or transient ischemic attack. Official Title A Double-Blind, Randomized, Placebo- Controlled Study Of Atorvastatin As Prevention Of Cerebrovascular Events In Patients With A Previous Transient Ischemic Attack (TIA) Or Stroke Conditions Stroke,…
Heart
01 Jan 2013
Efficacy & Safety of Dronedarone Versus Amiodarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation (DIONYSOS)
The objective of this study is to compare the efficacy and safety of dronedarone to that of amiodarone for the treatment of patients with atrial fibrillation. Official Title Randomized DB Trial to Evaluate Efficacy & Safety of Dronedarone (400mg BID) Versus Amiodarone (600mg Daily for 28 Days, Then 200mg Daily…
