Hormones
01 Jan 2013
Jugular Vein Sampling for Hormone Levels for the Diagnosis of Cushing Syndrome
Patients with Cushing’s disease have hormone producing tumours in their pituitary gland. Often these tumours are so small they cannot be detected by magnetic resonance imaging (MRI). The inferior petrosal sinuses are small veins that drain the blood from the pituitary gland. By taking a small sample of blood from…
Hormones
01 Jan 2013
PaTH Study: Parathyroid Hormone and Alendronate for Osteoporosis
This 2-year study will test the effectiveness of combining parathyroid hormone (PTH) and alendronate for treating osteoporosis in postmenopausal women. Alendronate is a drug used to treat osteoporosis and primarily prevents bone loss, whereas PTH increases bone formation. We will treat the study participants either with PTH and alendronate, alendronate…
Hormones
01 Jan 2013
Efficacy and Safety of an Oral Growth Hormone Drug in the Treatment of Fibromyalgia
This is a 24-week, randomised, double-blind, placebo-controlled, trial to evaluate the safety, tolerability and efficacy of an orally administered growth hormone stimulating drug, (code named MK-0677) in the treatment of female subjects with primary fibromyalgia. The basis for this study is the observation that many fibromyalgia patients are growth hormone…
Hormones
01 Jan 2013
Ghrelin, Growth Hormone and Cortisol Interaction in Growth Hormone Deficient Patients
In growth hormone deficient patients: Determination of endogenous circulating ghrelin levels, ghrelin effects on insulin sensitivity, appetite, energy metabolism, and signal transduction in fat and muscle. Official Title Effects of Acute Ghrelin Infusion to Growth Hormone Deficient Adults: Growth Hormone and Cortisol Interaction. Conditions Hypopituitarism Study Type Interventional Study…
Bone
01 Jan 2013
Effect of Growth Hormone on Bone Metabolism in Anorexia Nervosa
Decreased bone strength is a serious medical problem present in many women with Anorexia Nervosa, or disordered eating. Women with weaker bones are more likely to suffer broken bones than women with normal bone strength. We are investigating whether a hormone that is naturally produced by the human body, called…
Bone
01 Jan 2013
Growth Hormone Therapy in Osteogenesis Imperfecta
Growth deficiency is a key feature of severe Osteogenesis Imperfecta (OI) and a frequent feature of mild to moderate forms of the disease. The reason that children with OI are short is not fully understood. We do know that details such as the number of fractures suffered or the type…
Hormones
01 Jan 2013
Testosterone-Driven Growth-Hormone (GH) Secretion in Aging Men
This study is being done to understand how testosterone, the major male sex hormone, controls the pituitary gland’s secretion of growth hormone (GH). GH is an important metabolic hormone, which controls sugar; fat and protein use in the body and maintains muscle strength and bone calcium content. Both testosterone and…
Gastro
01 Jan 2013
Optical Coherence Tomography of the Gastrointestinal Tract (OCT)
Optical coherence tomography (OCT) is a non-invasive imaging technique that uses light to create pictures of living tissues and has been successfully used to generate high resolution cross-sectional images of tissue in the human eye and skin. OCT systems are now commercially available for eye and skin use, and several…
Bone
01 Jan 2013
Hypovitaminosis D and an Inadequate PTH Response in Chronic Liver Disease Patients
The purpose of this study is to determine how common low levels of magnesium are in patients with end stage liver disease. In addition, investigator is trying to determine if low levels of magnesium affect the release of parathyroid hormone in patients with end stage liver disease and low vitamin…
