Children's health
01 Jan 2013
Trial of Intranasal Insulin in Children and Young Adults at Risk of Type 1 Diabetes
In people with type I diabetes the beta cells of the pancreas no longer make insulin because the body’s immune system has attacked and destroyed the beta cells. It is thought that exposure of the mucous membranes to insulin may cause act like a vaccine effect whereby protective immune cells…
Hormones
01 Jan 2013
Comparison of Two Basal Insulin Therapies for Patients With Type 1 Diabetes (IOOZ)
The purpose of this study is to examine the effectiveness and safety of lispro protamine suspension as compared to insulin detemir as basal plus mealtime insulin therapy in patients with type 1 diabetes. Official Title Comparison of Two Basal Insulin Analogs (Insulin Lispro Protamine Suspension and Insulin Detemir) in Basal-Bolus…
Hormones
01 Jan 2013
Thyroid-Associated Ophthalmopathy Subtypes and Orbital Antibodies in patients with hyperthyroidism due to Graves’ disease
The purpose of this study is to determine whether radioactive iodine, as compared to anti-thyroid medications, is a risk factor for the development or progression of thyroid-associated ophthalmopathy in patients with hyperthyroidism due to Graves’ disease. The other aim of this study is to determine the incidence of the various…
Hormones
01 Jan 2013
The DURABLE Trial: Evaluating the Durability of Starter Insulin Regimens in Patients With Type 2 Diabetes
This study will compare insulin lispro low mixture and insulin glargine in combination with the patient’s oral diabetes medicines for their ability to control blood sugar in patients with type 2 diabetes and compare insulin lispro LM to insulin glargine with regard to the length of time that the overall…
Cancer
01 Jan 2013
Vinflunine in Patients With Locally Advanced or Metastatic Transitional Cell Carcinoma of the Urothelium
The purpose of this clinical research study is to learn if vinflunine can shrink or slow the growth of the cancer or increase survival in patients with transitional cell carcinoma of the urothelium. The safety of this treatment will also be studied. Official Title A Phase II Study of Intravenous…
Cancer
01 Jan 2013
SU011248 Versus Interferon-Alfa As First-Line Systemic Therapy For Patients With Metastatic Renal Cell Carcinoma
The purpose of this study is to test whether SU011248 has activity and is safe compared to interferon-alfa as first-line therapy in patients with metastatic renal cell carcinoma (RCC). Official Title A Phase 3, Randomized Study Of SU011248 Versus Interferon-Alfa As First-Line Systemic Therapy For Patients With Metastatic Renal Cell…
Research and Trials
01 Jan 2013
Freedom Study: Myfortic in Kidney Transplant Patients
The primary objective of the study is to evaluate that 3 immunosuppressant regimens will have comparable kidney function results in kidney transplant patients. Official Title Study to Investigate the Clinical Outcomes of Different Regimens of ‘Myfortic’ in De Novo Kidney Tx Pts Using ‘Simulect’ and ‘Neoral’ With or Without Steroids…
Research and Trials
01 Jan 2013
A Study of BMS-224818 (Belatacept) in Patients Who Have Undergone a Kidney Transplant and Are Currently on Stable Cyclosporine or Tacrolimus Regimen With or Without Corticosteroids
The purpose of this study is to learn if conversion to belatacept from cyclosporine or tacrolimus will preserve kidney function in people who have had a kidney transplant. The safety of this treatment will also be studied Official Title Belatacept Conversion Trial in Renal Transplantation Conditions Renal Transplant Study Type…
Research and Trials
01 Jan 2013
Using the Drug Spironolactone to Test If It Reduces Protein Leakage From the Kidney
The purpose of this study is to determine which combination of the tablets ramipril, irbesartan or spironolactone is best to lower protein leakage from the kidney. Protein leak from the kidney into the urine is an indicator of kidney damage. The higher the leak, the worse the damage and the…
